IUGR and IGF abnormalities
Gene: WRN
WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 18 panels
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 18 panels
2 reviews
Philip Murray (University of Manchester)
Peter Clayton (University of Manchester)
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- Emory Genetics Laboratory
- Phenotypes
-
- Werner syndrome
- OMIM
- 604611
- Clinvar variants
- Variants in WRN
- Penetrance
- Complete
- Panels with this gene
-
- Skeletal dysplasia
- Bilateral congenital or childhood onset cataracts
- Sarcoma cancer susceptibility
- Intellectual disability
- Primary ovarian insufficiency
- Insulin resistance (including lipodystrophy)
- Monogenic diabetes
- Severe insulin resistance and lipodystrophy syndromes
- Sarcoma susceptibility
- Osteogenesis imperfecta
- Monogenic short stature
- IUGR and IGF abnormalities
- Childhood solid tumours
- Sarcoma of possible germline origin
- Inherited non-medullary thyroid cancer
- Thyroid cancer pertinent cancer susceptibility
- Structural eye disease
- Childhood solid tumours cancer susceptibility
History Filter Activity
25 Apr 2016, Gel status: 4
Gene classified by Genomics England curator
emma baple (Genomics England Curator)This gene has been classified as Green List (High Evidence).
25 Apr 2016, Gel status: 4
Set Phenotypes
emma baple (Genomics England Curator)Phenotypes for WRN were set to Werner syndrome
25 Apr 2016, Gel status: 4
Set Mode of Inheritance
emma baple (Genomics England Curator)Mode of inheritance for WRN was changed to BIALLELIC, autosomal or pseudoautosomal
25 Apr 2016, Gel status: 4
Gene classified by Genomics England curator
emma baple (Genomics England Curator)This gene has been classified as Green List (High Evidence).
28 Apr 2015, Gel status: 1
Added New Source
GEL ()WRN was added to IUGR and IGF abnormalitiespanel. Sources: Emory Genetics Laboratory