IUGR and IGF abnormalities

Gene: ORC4

Green List (high evidence)

ORC4 (origin recognition complex subunit 4)
EnsemblGeneIds (GRCh38): ENSG00000115947
EnsemblGeneIds (GRCh37): ENSG00000115947
OMIM: 603056, Gene2Phenotype
ORC4 is in 5 panels

3 reviews

Peter Clayton (University of Manchester)

Green List (high evidence)

Philip Murray (University of Manchester)

Green List (high evidence)

emma baple (Genomics England Curator)

Comment on phenotypes: Meier Gorlin
3 Apr 2016, 8:20 p.m.

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • micrognathia, patellar aplasia/hypoplasia, microtia, mammary hypoplasia
OMIM
603056
Clinvar variants
Variants in ORC4
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

3 Apr 2016, Gel status: 4

Gene classified by Genomics England curator

emma baple (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

3 Apr 2016, Gel status: 4

Set Phenotypes

emma baple (Genomics England Curator)

Phenotypes for ORC4 were set to micrognathia, patellar aplasia/hypoplasia, microtia, mammary hypoplasia

3 Apr 2016, Gel status: 4

Gene classified by Genomics England curator

emma baple (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

23 Oct 2015, Gel status: 0

Created

Philip Murray (University of Manchester)

ORC4 was created by PhilMurray

23 Oct 2015, Gel status: 0

Added New Source

Philip Murray (University of Manchester)

ORC4 was added to IUGR and IGF abnormalitiespanel. Sources: Literature