IUGR and IGF abnormalities
Gene: WRNEnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 17 panels
2 reviews
Philip Murray (University of Manchester)
Peter Clayton (University of Manchester)
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- Emory Genetics Laboratory
- Phenotypes
-
- Werner syndrome
- OMIM
- 604611
- Clinvar variants
- Variants in WRN
- Penetrance
- Complete
- Panels with this gene
-
- Sarcoma cancer susceptibility
- Primary ovarian insufficiency
- Insulin resistance (including lipodystrophy)
- Monogenic short stature
- Osteogenesis imperfecta
- Bilateral congenital or childhood onset cataracts
- Sarcoma susceptibility
- Childhood solid tumours
- Monogenic diabetes
- Lipodystrophy - childhood onset
- IUGR and IGF abnormalities
- Structural eye disease
- Inherited non-medullary thyroid cancer
- Skeletal dysplasia
- Thyroid cancer pertinent cancer susceptibility
- Childhood solid tumours cancer susceptibility
- Intellectual disability
History Filter Activity
Gene classified by Genomics England curator
emma baple (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Set Phenotypes
emma baple (Genomics England Curator)Phenotypes for WRN were set to Werner syndrome
Set Mode of Inheritance
emma baple (Genomics England Curator)Mode of inheritance for WRN was changed to BIALLELIC, autosomal or pseudoautosomal
Gene classified by Genomics England curator
emma baple (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Added New Source
GEL ()WRN was added to IUGR and IGF abnormalitiespanel. Sources: Emory Genetics Laboratory