Inherited ovarian cancer (without breast cancer)
Gene: MLH1Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 2 (MIM# 609310); Mismatch repair cancer syndrome 1 (MIM# 276300); Muir-Torre syndrome (MIM# 158320)Created: 3 Mar 2021, 12:18 p.m. | Last Modified: 3 Mar 2021, 2:31 p.m.
Panel Version: 2.20
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 31 Jul 2019, 12:23 p.m. | Last Modified: 31 Jul 2019, 12:23 p.m.
Panel Version: 1.9
Publications
Variants in this GENE are reported as part of current diagnostic practice
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Variants in this GENE are reported as part of current diagnostic practice
Comment on list classification: This gene is reported as part of pertinent germline findings for the Cancer Programme for patients with ovarian cancer.Created: 30 May 2017, 11:26 a.m.
Comment on list classification: Promoted to green after review by Clare Turnbull.Created: 30 May 2017, 10:57 a.m.
Phenotypes for gene: MLH1 were changed from Adult Glioma; Colorectal; Endometrial Carcinoma; Hepatopancreatobiliary; Ovarian to Ovarian cancer, MONDO:0008170
Publications for gene: MLH1 were set to
Source Expert List was added to MLH1. Source NHS GMS was added to MLH1. Rating Changed from Green List (high evidence) to Green List (high evidence)
31/07/2017: Promoted panel to version 1, after checking against the original list sent by Clare Turnbull for this panel.
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
Phenotypes for MLH1 were set to Adult Glioma; Colorectal; Endometrial Carcinoma; Hepatopancreatobiliary; Ovarian
Mode of inheritance for MLH1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
This gene has been classified as Green List (High Evidence).
MLH1 was added to Familial ovarian cancerpanel. Sources: Emory Genetics Laboratory
MLH1 was created by ellenmcdonagh