Inherited ovarian cancer (without breast cancer)

Gene: PMS2

Amber List (moderate evidence)

PMS2 (PMS1 homolog 2, mismatch repair system component)
EnsemblGeneIds (GRCh38): ENSG00000122512
EnsemblGeneIds (GRCh37): ENSG00000122512
OMIM: 600259, Gene2Phenotype
PMS2 is in 32 panels

3 reviews

Ivone Leong (Genomics England Curator)

As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.
Created: 31 Jul 2019, 12:24 p.m. | Last Modified: 31 Jul 2019, 12:24 p.m.
Panel Version: 1.9

Lara Hawkes (Genomics England)

I don't know

Ellen McDonagh (Genomics England Curator)

Comment on list classification: This gene is reported as part of pertinent germline findings for the Cancer Programme for patients with ovarian cancer.
Created: 30 May 2017, 11:37 a.m.

History Filter Activity

29 Jan 2019, Gel status: 2

Added New Source

Ivone Leong (Genomics England Curator)

Source Expert List was added to PMS2.

31 Jul 2017, Gel status: 2

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

31/07/2017: Promoted panel to version 1, after checking against the original list sent by Clare Turnbull for this panel.

30 May 2017, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for PMS2 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

30 May 2017, Gel status: 2

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

26 May 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

PMS2 was created by ellenmcdonagh

26 May 2017, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

PMS2 was added to Familial ovarian cancerpanel. Sources: Emory Genetics Laboratory