Inherited ovarian cancer (without breast cancer)
Gene: RAD51D

RAD51D (RAD51 paralog D)
EnsemblGeneIds (GRCh38): ENSG00000185379
EnsemblGeneIds (GRCh37): ENSG00000185379
OMIM: 602954, Gene2Phenotype
RAD51D is in 6 panels

5 reviews

Ivone Leong (Genomics England Curator)

As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.
Created: 31 Jul 2019, 12:24 p.m. | Last Modified: 31 Jul 2019, 12:24 p.m.

Panel Version: 1.9

Created: 31 Jul 2019, 12:24 p.m.
Last Modified: 31 Jul 2019, 12:24 p.m.
Panel version: 1.9

Rachel Robinson (Leeds Genetics Laboratory)

Green List (high evidence)

Publications

29661970

Variants in this GENE are reported as part of current diagnostic practice

Created: 29 Jan 2019, 4:32 p.m.

Panel version: 1.5

Lara Hawkes (Genomics England)

Green List (high evidence)

Created: 29 Jan 2019, 4:32 p.m.

Panel version: 1.5

Treena Cranston (Oxford)

Green List (high evidence)

relative risk ~6
Created: 29 Aug 2017, 1:18 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Created: 29 Aug 2017, 1:18 p.m.

Panel version: 1.0

Ellen McDonagh (Genomics England Curator)

Comment on list classification: This gene is reported as part of pertinent germline findings for the Cancer Programme for patients with ovarian cancer.
Created: 30 May 2017, 11:28 a.m.

Created: 30 May 2017, 11:28 a.m.

Panel version: 0.20

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

NHS GMS
Expert List
Expert Review Green
Emory Genetics Laboratory
Radboud University Medical Center, Nijmegen
Illumina TruGenome Clinical Sequencing Services

Phenotypes

{Breast-ovarian cancer, familial, susceptibility to, 4}, OMIM:614291
Breast-ovarian cancer, familial, susceptibility to, 4, MONDO:0013669

OMIM

602954

Clinvar variants

Variants in RAD51D

Penetrance

Complete

Publications

29661970

Panels with this gene

History Filter Activity

3 Mar 2021, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: RAD51D were changed from {Breast-ovarian cancer, familial, susceptibility to, 4}, 614291; Breast and Ovarian Cancer; Breast and Ovarian Cancer Susceptibility to {Breast-ovarian cancer, familial, susceptibility to, 4}, OMIM:614291; Breast-ovarian cancer, familial, susceptibility to, 4, MONDO:0013669

3 Mar 2021, Gel status: 3

Set publications

Arina Puzriakova (Genomics England Curator)

Publications for gene: RAD51D were set to

29 Jan 2019, Gel status: 3

Added New Source, Added New Source, Status Update

Ivone Leong (Genomics England Curator)

Source Expert List was added to RAD51D. Source NHS GMS was added to RAD51D. Rating Changed from Green List (high evidence) to Green List (high evidence)

31 Jul 2017, Gel status: 4