Cytopenias and congenital anaemias
Gene: FCGR3B

FCGR3B (Fc fragment of IgG receptor IIIb)
EnsemblGeneIds (GRCh38): ENSG00000162747
EnsemblGeneIds (GRCh37): ENSG00000162747
OMIM: 610665, Gene2Phenotype
FCGR3B is in 4 panels

1 review

Helen Brittain (Genomics England Curator)

Red List (low evidence)

Relevant phenotype affects neutrophils only, on a transient basis owing to presence of antibodies in mother and antigen in fetus (as a result of different genetic factors in father and mother.). Therefore not a germline condition associated with mutations in the child.
Created: 9 Mar 2017, 4:32 p.m.

Mode of inheritance
Other - please specify in evaluation comments

Phenotypes
Neutropenia, alloimmune neonatal

Created: 9 Mar 2017, 4:32 p.m.

Panel version: 0.522

Details

Mode of Inheritance

Other - please specify in evaluation comments

Sources

Expert Review Red
Radboud University Medical Center, Nijmegen

Phenotypes

Neutropenia,alloimmuneneonatal

OMIM

610665

Clinvar variants

Variants in FCGR3B

Penetrance

Complete

Panels with this gene

History Filter Activity

11 Mar 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

9 Mar 2017, Gel status: 1

Set Mode of Inheritance, Added New Source

Sarah Leigh (Genomics England Curator)

FCGR3B was added to Cytopaenias and congenital anaemiaspanel. Source: Expert Review Red Model of inheritance for gene FCGR3B was set to Other - please specify in evaluation comments

17 Feb 2017, Gel status: 1

Added New Source

Louise Daugherty (Genomics England Curator)

FCGR3B was added to Cytopaenias and congenital anaemiaspanel. Sources: Radboud University Medical Center, Nijmegen

17 Feb 2017, Gel status: 0

Created