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Cytopenias and congenital anaemias
Gene: IRF1

IRF1 (interferon regulatory factor 1)
EnsemblGeneIds (GRCh38): ENSG00000125347
EnsemblGeneIds (GRCh37): ENSG00000125347
OMIM: 147575, Gene2Phenotype
IRF1 is in 3 panels

1 review

Helen Brittain (Genomics England Curator)

Red List (low evidence)

Somatic mutations are implicated in a number of cancers. This is out of scope for this panel and the rare disease arm of the project.
Created: 9 Mar 2017, 4:32 p.m.

Mode of inheritance
Unknown

Phenotypes
Myelodysplastic syndrome, preleukemic; Myelogenous leukemia, acute; Gastric cancer, somatic, 613659; Nonsmall cell lung cancer, somatic, 211980

Created: 9 Mar 2017, 4:32 p.m.

Panel version: 0.522

Details

Mode of Inheritance

Unknown

Sources

Expert Review Red
Radboud University Medical Center, Nijmegen

Phenotypes

Myelodysplastic syndrome, preleukemic
Myelogenous leukemia, acute
Gastric cancer, somatic, 613659
Nonsmall cell lung cancer, somatic, 211980

Tags

somatic

OMIM

147575

Clinvar variants

Variants in IRF1

Penetrance

Complete

Panels with this gene

History Filter Activity

11 Mar 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

9 Mar 2017, Gel status: 1

Set Mode of Inheritance, Added New Source

Sarah Leigh (Genomics England Curator)

IRF1 was added to Cytopaenias and congenital anaemiaspanel. Source: Expert Review Red Model of inheritance for gene IRF1 was set to Unknown

17 Feb 2017, Gel status: 1

Added New Source

Louise Daugherty (Genomics England Curator)

IRF1 was added to Cytopaenias and congenital anaemiaspanel. Sources: Radboud University Medical Center, Nijmegen

17 Feb 2017, Gel status: 0

Created