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Cytopenias and congenital anaemias
Gene: TET2

TET2 (tet methylcytosine dioxygenase 2)
EnsemblGeneIds (GRCh38): ENSG00000168769
EnsemblGeneIds (GRCh37): ENSG00000168769
OMIM: 612839, Gene2Phenotype
TET2 is in 3 panels

2 reviews

Helen Brittain (Genomics England Curator)

Red List (low evidence)

Somatic. Mutations associated with MDS and myeloid tumorigenesis
Created: 9 Mar 2017, 4:32 p.m.

Mode of inheritance
Other - please specify in evaluation comments

Phenotypes
Myelodysplastic syndrome, somatic, 614286

Created: 9 Mar 2017, 4:32 p.m.

Panel version: 0.522

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

Mode of inheritance
Unknown

Phenotypes
Myelodysplastic syndrome (MDS), Paediatric

Variants in this GENE are reported as part of current diagnostic practice

Created: 16 Jan 2017, 3:47 p.m.

Panel version: Imported from "Anaemias and red cell disorders" panel version 0.9

Details

Mode of Inheritance

Other - please specify in evaluation comments

Sources

Expert Review Red
Radboud University Medical Center, Nijmegen

Phenotypes

Myelodysplastic syndrome, somatic, 614286

Tags

somatic

OMIM

612839

Clinvar variants

Variants in TET2

Penetrance

Complete

Panels with this gene

History Filter Activity

11 Mar 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

9 Mar 2017, Gel status: 1

Set Mode of Inheritance, Added New Source

Sarah Leigh (Genomics England Curator)

TET2 was added to Cytopaenias and congenital anaemiaspanel. Source: Expert Review Red Model of inheritance for gene TET2 was set to Other - please specify in evaluation comments

17 Feb 2017, Gel status: 0

Created

Louise Daugherty (Genomics England Curator)

TET2 was created by LouiseD

17 Feb 2017, Gel status: 1

Added New Source