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Cytopenias and congenital anaemias
Gene: ZRSR2

ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2)
EnsemblGeneIds (GRCh38): ENSG00000169249
EnsemblGeneIds (GRCh37): ENSG00000169249
OMIM: 300028, Gene2Phenotype
ZRSR2 is in 2 panels

2 reviews

Rebecca Foulger (Genomics England curator)

Comment on list classification: Kept rating as red because COSMIC and literature (e.g. PMID:27543316, PMID:25550361) support somatic variants as causative for AML.
Created: 9 Mar 2017, 3:30 p.m.

Somatic variants only, reported in COSMIC cancer gene census.
Created: 9 Mar 2017, 3:18 p.m.

Created: 9 Mar 2017, 3:18 p.m.

Panel version: 0.512

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

Mode of inheritance
Unknown

Phenotypes
Acute myeloid leukaemia (AML); Chronic Myeloid Leukemia (CML)

Variants in this GENE are reported as part of current diagnostic practice

Created: 16 Jan 2017, 3:47 p.m.

Panel version: Imported from "Anaemias and red cell disorders" panel version 0.9

Details

Mode of Inheritance

Unknown

Sources

Expert Review Red
BRIDGE consortium (NIHRBR-RD)

Phenotypes

Acute myeloid leukaemia (AML)
Chronic Myeloid Leukemia (CML)

Tags

somatic

OMIM

300028

Clinvar variants

Variants in ZRSR2

Penetrance

Complete

Publications

Panels with this gene

History Filter Activity

11 Mar 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

9 Mar 2017, Gel status: 1

Gene classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

This gene has been classified as Red List (Low Evidence).

9 Mar 2017, Gel status: 0

Set publications

Rebecca Foulger (Genomics England curator)

Publications for ZRSR2 were set to 25550361; 27543316; 22389253

17 Feb 2017, Gel status: 0

Created

Louise Daugherty (Genomics England Curator)

ZRSR2 was created by LouiseD