Inherited non-medullary thyroid cancer
Gene: FOXE1

FOXE1 (forkhead box E1)
EnsemblGeneIds (GRCh38): ENSG00000178919
EnsemblGeneIds (GRCh37): ENSG00000178919
OMIM: 602617, Gene2Phenotype
FOXE1 is in 7 panels

3 reviews

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with phenotype in OMIM, not in G2P. At least one variant reported in two apparently unrelated cases, supportive animal cell line data also available (PMID: 25381600)
Created: 31 Jul 2017, 12:34 p.m.

Comment on phenotypes: Biallelic variants associated with Bamforth-Lazarus syndrome 241850
Created: 31 Jul 2017, 12:30 p.m.

Created: 31 Jul 2017, 12:30 p.m.

Panel version: 0.41

Emma Woodward (Manchester Centre for Genomic Medicine)

Red List (low evidence)

SNP 60kb from FOXE1 has shown association with NMTC in GWAS studies but no causative role of FOXE1 been demonstrated as yet.
Created: 13 Jun 2017, 2:06 p.m.

Created: 13 Jun 2017, 2:06 p.m.

Panel version: 0.5

Fiona Lalloo (Manchester Centre for Genomic Medicine)

Red List (low evidence)

GWAS suggest some association but not clear. No clinical utility
Created: 9 Jun 2017, 9:10 a.m.

Created: 9 Jun 2017, 9:10 a.m.

Panel version: 0.5

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

Expert Review Amber
Radboud University Medical Center, Nijmegen

Phenotypes

{Thyroid cancer, nonmedullary, 4} 616534

OMIM

602617

Clinvar variants

Variants in FOXE1

Penetrance

Complete

Publications

25381600

Panels with this gene