Inherited non-medullary thyroid cancer
Gene: KISS1R

KISS1R (KISS1 receptor)
EnsemblGeneIds (GRCh38): ENSG00000116014
EnsemblGeneIds (GRCh37): ENSG00000116014
OMIM: 604161, Gene2Phenotype
KISS1R is in 4 panels

3 reviews

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Not associated with phenotype in OMIM or G2P. No variants reported. Increased expression of KISS1 is possibly acquired to prevent further tumor invasiveness and formation of local or distant metastasis. It appears that malignant cells in DTC express increased levels of KISS1 as the tumor invades extrathyroidal tissues. Decreased expression of KISS1R seems to attenuate signaling of the KISS1/KISS1R system, possibly leading to tumor growth (PMID 25667462)
Created: 7 Aug 2017, 8:54 a.m.

Created: 7 Aug 2017, 8:54 a.m.

Panel version: 0.46

Emma Woodward (Manchester Centre for Genomic Medicine)

I am not aware of any evidence linking germline mutation with predisposition to NMTC
Created: 13 Jun 2017, 2:15 p.m.

Created: 13 Jun 2017, 2:15 p.m.

Panel version: 0.5

Fiona Lalloo (Manchester Centre for Genomic Medicine)

Red List (low evidence)

No association with thyroid malignancy
Created: 9 Jun 2017, 9:22 a.m.

Created: 9 Jun 2017, 9:22 a.m.

Panel version: 0.5

Details

Mode of Inheritance

Unknown

Sources

Expert Review Red
Literature

Phenotypes

Somatic follicular and papillary thyroid carcinomas

OMIM

604161

Clinvar variants

Variants in KISS1R

Penetrance

Complete

Publications

Panels with this gene