Inherited non-medullary thyroid cancer
Gene: VTRNA2-1
VTRNA2-1 (vault RNA 2-1)
EnsemblGeneIds (GRCh38): ENSG00000270123
EnsemblGeneIds (GRCh37): ENSG00000270123
OMIM: 614938, Gene2Phenotype
VTRNA2-1 is in 1 panel
EnsemblGeneIds (GRCh38): ENSG00000270123
EnsemblGeneIds (GRCh37): ENSG00000270123
OMIM: 614938, Gene2Phenotype
VTRNA2-1 is in 1 panel
2 reviews
Sarah Leigh (Genomics England Curator)
Over expression of VTRNA2-1 in thyroid cancer cell lines increased the number of cells in S phase and inhibited cell proliferation, formation of spheroids in suspension cultures, and cell migration in adherent cultures, this was associated with increased CDC6 (602627) protein expression and activity (PMID 21998631).Created: 7 Aug 2017, 1:03 p.m.
Emma Woodward (Manchester Centre for Genomic Medicine)
no evidence of clinical utilityCreated: 13 Jun 2017, 3:50 p.m.
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Literature
- Phenotypes
-
- familial papillary thyroid cancers
- Tags
- OMIM
- 614938
- Clinvar variants
- Variants in VTRNA2-1
- Penetrance
- Complete
- Publications
- Panels with this gene
History Filter Activity
17 Nov 2020, Gel status: 1
Added Tag
Sarah Leigh (Genomics England Curator)Tag locus-type-rna-vault tag was added to gene: VTRNA2-1.
7 Aug 2017, Gel status: 0
panel promoted to version 1
Sarah Leigh (Genomics England Curator)All genes have been reviewed and the reviews evaluated. 07.08.2017
18 May 2017, Gel status: 0
Created
Sarah Leigh (Genomics England Curator)VTRNA2-1 was created by sleigh
18 May 2017, Gel status: 0
Added New Source
Sarah Leigh (Genomics England Curator)VTRNA2-1 was added to Inherited non-medullary thyroid cancerpanel. Sources: Literature