Inherited non-medullary thyroid cancer
Gene: WRNEnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 17 panels
3 reviews
Emma Woodward (Manchester Centre for Genomic Medicine)
Can be included, although other phenotypic features of Werner would be apparent as their penetrance is much higher than for NTMC in Werner.Created: 13 Jun 2017, 6:30 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Fiona Lalloo (Manchester Centre for Genomic Medicine)
Should pick up this diagnosis clinically. Is clear evidence of association with thyroid malignancyCreated: 9 Jun 2017, 8:26 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Werner Syndrome
Publications
Variants in this GENE are reported as part of current diagnostic practice
Sarah Leigh (Genomics England Curator)
Comment when marking as ready: Thyroid cancers have been associated with Werner syndrome 277700. WRN associated with Werner syndrome 277700 in OMIM and as a confirmed G2P. At least 10 variants reported.Created: 10 Jul 2017, 12:57 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Werner syndrome 277700
Publications
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- UKGTN
- Emory Genetics Laboratory
- Illumina TruGenome Clinical Sequencing Services
- Radboud University Medical Center, Nijmegen
- Literature
- Phenotypes
-
- Werner syndrome 277700
- OMIM
- 604611
- Clinvar variants
- Variants in WRN
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Sarcoma cancer susceptibility
- Primary ovarian insufficiency
- Insulin resistance (including lipodystrophy)
- Monogenic short stature
- Osteogenesis imperfecta
- Bilateral congenital or childhood onset cataracts
- Sarcoma susceptibility
- Childhood solid tumours
- Lipodystrophy - childhood onset
- IUGR and IGF abnormalities
- Structural eye disease
- Inherited non-medullary thyroid cancer
- Skeletal dysplasia
- Thyroid cancer pertinent cancer susceptibility
- Childhood solid tumours cancer susceptibility
- Monogenic diabetes
- Intellectual disability
History Filter Activity
panel promoted to version 1
Sarah Leigh (Genomics England Curator)All genes have been reviewed and the reviews evaluated. 07.08.2017
Gene classified by Genomics England curator
Sarah Leigh (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Set publications
Sarah Leigh (Genomics England Curator)Publications for WRN were set to 8722214; 23573208; 8602509
Added New Source
Sarah Leigh (Genomics England Curator)WRN was added to Inherited non-medullary thyroid cancerpanel. Sources: UKGTN,Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Literature
Created
Sarah Leigh (Genomics England Curator)WRN was created by sleigh