Inherited bleeding disorders
Gene: PROS1
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Phenotypes
Protein S deficiency
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Phenotypes
Protein S deficiency
Variants in this GENE are reported as part of current diagnostic practice
Eligibility statement prior genetic testing was added to PROS1. Panel: Inherited bleeding disorders
Revised 19 December 2016
PROS1 was added to Inherited bleeding disorderspanel. Source: UKGTN PROS1 was added to Inherited bleeding disorderspanel. Source: Radboud University Medical Center, Nijmegen PROS1 was added to Inherited bleeding disorderspanel. Source: Illumina TruGenome Clinical Sequencing Services Model of inheritance for gene PROS1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
PROS1 was added to Inherited bleeding disorderspanel. Source: Expert Review Green Model of inheritance for gene PROS1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
PROS1 was created by ellenmcdonagh
PROS1 was added to Inherited bleeding disorderspanel. Sources: BRIDGE Study Tier 1 Gene