1. Panels
  2. Multiple Tumours
  3. ALK
STRs in panel
Prev Next
Regions in panel
Prev Next

Multiple Tumours

Gene: ALK

Green List (high evidence)
ALK (ALK receptor tyrosine kinase)
EnsemblGeneIds (GRCh38): ENSG00000171094
EnsemblGeneIds (GRCh37): ENSG00000171094
OMIM: 105590, Gene2Phenotype
ALK is in 4 panels

1 review

Ellen McDonagh (Genomics England Curator)

Information from TruSight panel: Pathogenic Mutations are Activating.
Created: 5 Feb 2016, 11:46 a.m.

Mode of pathogenicity
Other - please provide details in the comments

Created: 5 Feb 2016, 11:46 a.m.

Panel version: 0.2

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • TruSight Cancer Panel (Illumina)
Phenotypes
  • Neuroblastoma
  • Paediatric congenital malformation-dysmorphism-tumour syndromes
OMIM
105590
Clinvar variants
Variants in ALK
Penetrance
Complete
Panels with this gene

History Filter Activity

9 Mar 2016, Gel status: 4

Set Mode of Inheritance, Added New Source

Ellen McDonagh (Genomics England Curator)

ALK was added to Multiple Tumourspanel. Source: Expert Review Green Model of inheritance for gene ALK was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

5 Feb 2016, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

ALK was created by ellenmcdonagh

5 Feb 2016, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

ALK was added to Multiple Tumourspanel. Sources: TruSight Cancer Panel (Illumina)