This Panel is marked as Retired
Multiple Tumours
Gene: WRN
WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 18 panels
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 18 panels
1 review
Ellen McDonagh (Genomics England Curator)
Information from TruSight panel: Pathogenic Mutations are Inactivating.Created: 5 Feb 2016, 11:47 a.m.
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- TruSight Cancer Panel (Illumina)
- Phenotypes
-
- Werner Syndrome
- Sarcoma
- Melanoma
- Thyroid cancer
- OMIM
- 604611
- Clinvar variants
- Variants in WRN
- Penetrance
- Complete
- Panels with this gene
-
- Skeletal dysplasia
- Bilateral congenital or childhood onset cataracts
- Sarcoma cancer susceptibility
- Intellectual disability
- Primary ovarian insufficiency
- Insulin resistance (including lipodystrophy)
- Monogenic diabetes
- Severe insulin resistance and lipodystrophy syndromes
- Structural eye disease
- Sarcoma susceptibility
- Osteogenesis imperfecta
- Monogenic short stature
- IUGR and IGF abnormalities
- Childhood solid tumours
- Sarcoma of possible germline origin
- Inherited non-medullary thyroid cancer
- Thyroid cancer pertinent cancer susceptibility
- Childhood solid tumours cancer susceptibility
History Filter Activity
5 Feb 2016, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)WRN was created by ellenmcdonagh
5 Feb 2016, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)WRN was added to Multiple Tumourspanel. Sources: TruSight Cancer Panel (Illumina)