This Panel is marked as Retired
Multiple Tumours
Gene: STK11
STK11 (serine/threonine kinase 11)
EnsemblGeneIds (GRCh38): ENSG00000118046
EnsemblGeneIds (GRCh37): ENSG00000118046
OMIM: 602216, Gene2Phenotype
STK11 is in 14 panels
EnsemblGeneIds (GRCh38): ENSG00000118046
EnsemblGeneIds (GRCh37): ENSG00000118046
OMIM: 602216, Gene2Phenotype
STK11 is in 14 panels
1 review
Ellen McDonagh (Genomics England Curator)
Information from TruSight panel: Pathogenic Mutations are Inactivating.Created: 5 Feb 2016, 11:47 a.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- TruSight Cancer Panel (Illumina)
- Phenotypes
-
- Peutz-Jeghers SyndromeColorectal cancer, hamartoma, adenoma
- Gastric cancer, hamartoma, adenoma
- Breast cancer
- Ovarian cancer (epithelial, sex cord-stromal tumor)
- Testicular cancer (sex cord-stromal tumor)
- Pancreatic cancer
- Cervical cancer (adenoma malignum)
- Familial breast cancer
- Familial colon cancer
- OMIM
- 602216
- Clinvar variants
- Variants in STK11
- Penetrance
- Complete
- Panels with this gene
-
- Inherited pancreatic cancer
- Childhood solid tumours cancer susceptibility
- Colorectal cancer pertinent cancer susceptibility
- Adult solid tumours for rare disease
- Familial breast cancer
- Multiple monogenic benign skin tumours
- Inherited polyposis and early onset colorectal cancer - germline testing
- GI tract tumours
- Pigmentary skin disorders
- Palmoplantar keratodermas
- Adult solid tumours cancer susceptibility
- Childhood solid tumours
- Peutz Jeghers Syndrome
- Inherited ovarian cancer (without breast cancer)
History Filter Activity
9 Mar 2016, Gel status: 4
Set Mode of Inheritance, Added New Source
Ellen McDonagh (Genomics England Curator)STK11 was added to Multiple Tumourspanel. Source: Expert Review Green Model of inheritance for gene STK11 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
5 Feb 2016, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)STK11 was created by ellenmcdonagh
5 Feb 2016, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)STK11 was added to Multiple Tumourspanel. Sources: TruSight Cancer Panel (Illumina)