Multiple Tumours
Gene: SDHA

SDHA (succinate dehydrogenase complex flavoprotein subunit A)
EnsemblGeneIds (GRCh38): ENSG00000073578
EnsemblGeneIds (GRCh37): ENSG00000073578
OMIM: 600857, Gene2Phenotype
SDHA is in 27 panels

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Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Expert Review Green

Phenotypes

Neuro-endocrine Tumours- PCC and PGL

OMIM

600857

Clinvar variants

Variants in SDHA

Penetrance

Complete

Panels with this gene

Sarcoma susceptibility
Fetal anomalies
Dystonia, chorea or related movement disorder, childhood onset
Inherited predisposition to GIST
DDG2P
Neuroendocrine cancer pertinent cancer susceptibility
Possible mitochondrial disorder, nuclear genes
Mitochondrial disorders
White matter disorders and cerebral calcification - childhood onset
Structural basal ganglia disorders
Inherited phaeochromocytoma and paraganglioma
Adult solid tumours cancer susceptibility
Likely inborn error of metabolism
Left Ventricular Noncompaction Cardiomyopathy
Paediatric pseudo-obstruction syndrome
Paediatric or syndromic cardiomyopathy
Early onset or syndromic epilepsy
Dystonia, chorea or related movement disorder, adult onset
Sarcoma cancer susceptibility
Intellectual disability
Undiagnosed metabolic disorders
Dilated Cardiomyopathy and conduction defects
Optic neuropathy
Mitochondrial disorder with complex II deficiency
Inherited white matter disorders
Inherited phaeochromocytoma and paraganglioma excluding NF1
Adult solid tumours for rare disease

History Filter Activity

9 Mar 2016, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

SDHA was created by ellenmcdonagh

9 Mar 2016, Gel status: 4

Added New Source