Multiple Tumours
Gene: SDHA

SDHA (succinate dehydrogenase complex flavoprotein subunit A)
EnsemblGeneIds (GRCh38): ENSG00000073578
EnsemblGeneIds (GRCh37): ENSG00000073578
OMIM: 600857, Gene2Phenotype
SDHA is in 27 panels

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Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Expert Review Green

Phenotypes

Neuro-endocrine Tumours- PCC and PGL

OMIM

600857

Clinvar variants

Variants in SDHA

Penetrance

Complete

Panels with this gene

Early onset or syndromic epilepsy
Neuroendocrine cancer pertinent cancer susceptibility
Paediatric or syndromic cardiomyopathy
Inherited phaeochromocytoma and paraganglioma excluding NF1
Structural basal ganglia disorders
Inherited phaeochromocytoma and paraganglioma
Adult solid tumours cancer susceptibility
Left Ventricular Noncompaction Cardiomyopathy
Paediatric pseudo-obstruction syndrome
Mitochondrial disorder with complex II deficiency
Sarcoma cancer susceptibility
Undiagnosed metabolic disorders
Dilated Cardiomyopathy and conduction defects
White matter disorders and cerebral calcification - narrow panel
Childhood onset dystonia, chorea or related movement disorder
Adult onset dystonia, chorea or related movement disorder
Inherited white matter disorders
Possible mitochondrial disorder - nuclear genes
Adult solid tumours for rare disease
Optic neuropathy
Mitochondrial disorders
Intellectual disability
Sarcoma susceptibility
DDG2P
Inherited predisposition to GIST
Likely inborn error of metabolism
Fetal anomalies

History Filter Activity

9 Mar 2016, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

SDHA was created by ellenmcdonagh

9 Mar 2016, Gel status: 4

Added New Source