This Panel is marked as Retired
Multiple Tumours
Gene: DICER1
DICER1 (dicer 1, ribonuclease III)
EnsemblGeneIds (GRCh38): ENSG00000100697
EnsemblGeneIds (GRCh37): ENSG00000100697
OMIM: 606241, Gene2Phenotype
DICER1 is in 13 panels
EnsemblGeneIds (GRCh38): ENSG00000100697
EnsemblGeneIds (GRCh37): ENSG00000100697
OMIM: 606241, Gene2Phenotype
DICER1 is in 13 panels
1 review
Ellen McDonagh (Genomics England Curator)
Information from TruSight panel: Pathogenic Mutations are Inactivating.Created: 5 Feb 2016, 11:46 a.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- TruSight Cancer Panel (Illumina)
- Phenotypes
-
- DICER1 Syndrome
- Pleuropulmonary blastoma
- Cystic nephroma
- Ovarian sex cord tumor
- Paediatric congenital malformation-dysmorphism-tumour syndromes
- OMIM
- 606241
- Clinvar variants
- Variants in DICER1
- Penetrance
- Complete
- Panels with this gene
-
- Familial rhabdomyosarcoma
- Childhood solid tumours cancer susceptibility
- Adult solid tumours for rare disease
- Sarcoma of possible germline origin
- Adult solid tumours cancer susceptibility
- Sarcoma susceptibility
- DICER1-related cancer predisposition
- Sarcoma cancer susceptibility
- Embryonal tumour of possible germline origin
- COVID-19 research
- Childhood solid tumours
- Inherited non-medullary thyroid cancer
- Fetal anomalies
History Filter Activity
9 Mar 2016, Gel status: 4
Set Mode of Inheritance, Added New Source
Ellen McDonagh (Genomics England Curator)DICER1 was added to Multiple Tumourspanel. Source: Expert Review Green Model of inheritance for gene DICER1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
5 Feb 2016, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)DICER1 was created by ellenmcdonagh
5 Feb 2016, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)DICER1 was added to Multiple Tumourspanel. Sources: TruSight Cancer Panel (Illumina)