This Panel is marked as Retired
Multiple Tumours
Gene: WT1
WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 18 panels
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 18 panels
1 review
Ellen McDonagh (Genomics England Curator)
Information from TruSight panel: Pathogenic Mutations are Inactivating.Created: 5 Feb 2016, 11:47 a.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- TruSight Cancer Panel (Illumina)
- Phenotypes
-
- WAGR
- Denys-Drash Syndrome
- Frasier Syndrome Wilms tumor
- Gonadoblastoma
- Paediatric congenital malformation-dysmorphism-tumour syndromes
- OMIM
- 607102
- Clinvar variants
- Variants in WT1
- Penetrance
- Complete
- Panels with this gene
-
- Retinal disorders
- Glaucoma (developmental)
- Proteinuric renal disease
- Childhood solid tumours cancer susceptibility
- Structural eye disease
- Differences in sex development
- Embryonal tumour of possible germline origin
- Adult solid tumours cancer susceptibility
- Sarcoma cancer susceptibility
- Cytopenias and congenital anaemias
- Familial rhabdomyosarcoma
- Adult solid tumours for rare disease
- Intellectual disability
- Sarcoma susceptibility
- Unexplained kidney failure in young people
- DDG2P
- Childhood solid tumours
- Fetal anomalies
History Filter Activity
9 Mar 2016, Gel status: 4
Set Mode of Inheritance, Added New Source
Ellen McDonagh (Genomics England Curator)WT1 was added to Multiple Tumourspanel. Source: Expert Review Green Model of inheritance for gene WT1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
5 Feb 2016, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)WT1 was created by ellenmcdonagh
5 Feb 2016, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)WT1 was added to Multiple Tumourspanel. Sources: TruSight Cancer Panel (Illumina)