Retinal disorders
Gene: INTS11

INTS11 (integrator complex subunit 11)
EnsemblGeneIds (GRCh38): ENSG00000127054
EnsemblGeneIds (GRCh37): ENSG00000127054
OMIM: 611354, Gene2Phenotype
INTS11 is in 6 panels

1 review

Siying Lin (Moorfields Eye Hospital)

PMID 41810893 describes 4 patients from 2 unrelated families with a distinct inner retinopathy associated with INTS11-associated neurodevelopmental disorder, supporting this gene as a cause of syndromic IRD.
Sources: Literature
Created: 12 Mar 2026, 8:26 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Retinal dystrophy

Publications

PMID: 41810893

Mode of pathogenicity
Other

Created: 12 Mar 2026, 8:26 a.m.

Panel version: 8.98

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Phenotypes

Retinal dystrophy

OMIM

611354

Clinvar variants

Variants in INTS11

Penetrance

None

Publications

PMID: 41810893

Mode of Pathogenicity

Other

Panels with this gene

History Filter Activity

12 Mar 2026, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set mode of pathogenicity

Siying Lin (Moorfields Eye Hospital)

gene: INTS11 was added gene: INTS11 was added to Retinal disorders. Sources: Literature Mode of inheritance for gene: INTS11 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: INTS11 were set to PMID: 41810893 Phenotypes for gene: INTS11 were set to Retinal dystrophy Mode of pathogenicity for gene: INTS11 was set to Other

Retinal disorders Gene: INTS11