Inherited white matter disorders
Gene: TYROBP

TYROBP (TYRO protein tyrosine kinase binding protein)
EnsemblGeneIds (GRCh38): ENSG00000011600
EnsemblGeneIds (GRCh37): ENSG00000011600
OMIM: 604142, Gene2Phenotype
TYROBP is in 10 panels

2 reviews

Sarah Leigh (Genomics England Curator)

Comment on list classification: This gene is awaiting curator evaluation and rating.
Created: 19 Dec 2018, 1:05 p.m.

Created: 19 Dec 2018, 1:05 p.m.

Panel version: 1.51

Zornitza Stark (Australian Genomics)

Green List (high evidence)

Adult-onset early dementia, white matter abnormalities are a prominent feature.
Created: 24 Jul 2018, 11:52 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Nasu-Hakola disease, MIM#221770

Variants in this GENE are reported as part of current diagnostic practice

Created: 24 Jul 2018, 11:52 a.m.

Panel version: 1.19

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Expert Review Red

Phenotypes

Nasu-Hakola disease, MIM#221770

OMIM

604142

Clinvar variants

Variants in TYROBP

Penetrance

None

Panels with this gene

History Filter Activity

19 Dec 2018, Gel status: 1

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: tyrobp has been classified as Red List (Low Evidence).

24 Jul 2018, Gel status: 0

Added New Source

Zornitza Stark (Australian Genomics)

TYROBP was added to Inherited white matter disorders panel. Sources: Expert list

24 Jul 2018, Gel status: 0

Created