Inherited white matter disorders

Gene: MFF

Red List (low evidence)

MFF (mitochondrial fission factor)
EnsemblGeneIds (GRCh38): ENSG00000168958
EnsemblGeneIds (GRCh37): ENSG00000168958
OMIM: 614785, Gene2Phenotype
MFF is in 11 panels

2 reviews

Zornitza Stark (Australian Genomics)

Red List (low evidence)

Seems to predominantly affect the basal ganglia rather than white matter.
Created: 24 Jul 2018, 2:47 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

Inclusion of this as a green gene on this panel is appropriate, based on the review in the Undiagnosed metabolic disorders panel and the views of clinical expert, Dr Arianna Tucci, UCL.
Created: 20 Mar 2017, 10:46 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Encephalopathy due to defective mitochondrial and peroxisomal fission 2 617086

History Filter Activity

20 Mar 2017, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

MFF was created by sleigh

20 Mar 2017, Gel status: 0

Added New Source

Sarah Leigh (Genomics England Curator)

MFF was added to Inherited white matter disorderspanel. Sources: Expert Review