Inherited white matter disordersGene: DPYD
pharmacogenetic tag: Severe toxicity can occur with certain medications (eg, 5-fluorouracil), and precautions may be beneficial
Created: 16 Mar 2017, 2:40 p.m.
Inclusion of this as a green gene on this panel is appropriate, based on the review in the Undiagnosed metabolic disorders panel and the views of clinical expert, Dr Arianna Tucci, UCL.
Created: 16 Mar 2017, 2:37 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
5-fluorouracil toxicity 274270; Dihydropyrimidine dehydrogenase deficiency 274270
This gene has been classified as Green List (High Evidence).
DPYD was created by sleigh
DPYD was added to Inherited white matter disorderspanel. Sources: Expert Review