Inherited white matter disorders
Gene: DARSAdded new-gene-name tag, new approved HGNC gene symbol for DARS is DARS1Created: 6 Sep 2019, 11:39 a.m. | Last Modified: 6 Sep 2019, 11:39 a.m.
Panel Version: 1.71
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
General Leukodystrophy & Mitochondrial Leukoencephalopathy
Publications
Variants in this GENE are reported as part of current diagnostic practice
Comment when marking as ready: Associated with phenotype in G2P. Numerous variants reported in this phenotype.Created: 6 Jul 2016, 1:13 p.m.
Comment on list classification: Provisionally accepted by UKGTN for Combined leukodystrophy/mitochondrial leukoencephalopathy 94-gene panel (Ian Berry)Created: 6 Jul 2016, 1:12 p.m.
Tag new-gene-name tag was added to gene: DARS.
6th Oct 2016: Panel promoted to version 1 after expert review and input, further curation and clinical input.
This gene has been classified as Green List (High Evidence).
Publications for DARS were set to 25655951; 23643384
Phenotypes for DARS were set to Hypomyelination with brainstem and spinal cord involvement and leg spasticity 615281
This gene has been classified as Green List (High Evidence).
DARS was added to Inherited white matter disorderspanel. Sources: Expert list,Illumina TruGenome Clinical Sequencing Services
Publications for DARS were set to 25655951
Mode of inheritance for DARS was changed to BIALLELIC, autosomal or pseudoautosomal
DARS was added to Inherited white matter disorderspanel. Sources: Radboud University Medical Center, Nijmegen
DARS was created by ellenmcdonagh