Genes in panel

Neurodegenerative disorders - adult onset

Gene: DAO

Amber List (moderate evidence)

DAO (D-amino acid oxidase)
EnsemblGeneIds (GRCh38): ENSG00000110887
EnsemblGeneIds (GRCh37): ENSG00000110887
OMIM: 124050, Gene2Phenotype
DAO is in 1 panel

2 reviews

Louise Daugherty (Genomics England Curator)

I don't know

As discussed with the GMS Neurology Specialist Test Group webex call 11th September 2019: The Specialist Test Group all agreed that there is only enough evidence to rate this gene Amber
Created: 20 Sep 2019, 4:19 p.m. | Last Modified: 20 Sep 2019, 4:19 p.m.
Panel Version: 1.106
Review and rating submitted by Nick Beauchamp (Sheffield Diagnostic genetics Service), on behalf of Yorkshire and North East GLH for GMS Neurology specialist test group.
Created: 23 Jul 2019, 3:51 p.m. | Last Modified: 23 Jul 2019, 3:51 p.m.
Panel Version: 1.74

Nick Beauchamp (Sheffield Diagnostic Genetics Service)

Green List (high evidence)

Mutation identified in family expressed in mouse model. Other variants identified in sporadic cases.
Created: 23 Jul 2019, 3:35 p.m. | Last Modified: 23 Jul 2019, 3:35 p.m.
Panel Version: 1.72

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Amyotrophic lateral sclerosis

Publications

Variants in this GENE are reported as part of current diagnostic practice

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • NHS GMS
  • Yorkshire and North East GLH
Phenotypes
  • Amyotrophic lateral sclerosis
OMIM
124050
Clinvar variants
Variants in DAO
Penetrance
None
Publications
Panels with this gene

History Filter Activity

20 Sep 2019, Gel status: 2

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Amber was added to DAO. Rating Changed from Green List (high evidence) to Amber List (moderate evidence)

23 Jul 2019, Gel status: 3

Set mode of inheritance, Set Phenotypes, Set publications

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene DAO was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes Amyotrophic lateral sclerosis for gene: DAO Publications for gene DAO were changed from to 29194436; 20368421

23 Jul 2019, Gel status: 3

Added New Source

Louise Daugherty (Genomics England Curator)

Source NHS GMS was added to DAO.

23 Jul 2019, Gel status: 3

Added New Source

Louise Daugherty (Genomics England Curator)

Source Yorkshire and North East GLH was added to DAO.

23 Jul 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: DAO was added gene: DAO was added to Neurodegenerative disorders - adult onset. Sources: Expert Review Green Mode of inheritance for gene: DAO was set to