Adult onset neurodegenerative disorder
Gene: JAM2

JAM2 (junctional adhesion molecule 2)
EnsemblGeneIds (GRCh38): ENSG00000154721
EnsemblGeneIds (GRCh37): ENSG00000154721
OMIM: 606870, Gene2Phenotype
JAM2 is in 2 panels

1 review

Lucy Jackson (NHS)

Green List (high evidence)

Sources: Literature
Created: 4 Mar 2026, 9:16 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Basal ganglia calcification 8, 618824; Primary familial brain calcification; Fahr syndrome

Publications

Created: 4 Mar 2026, 9:16 a.m.

Panel version: 8.11

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Phenotypes

Basal ganglia calcification 7, 618317
Primary familial brain calcification
Fahr syndrome

OMIM

606870

Clinvar variants

Variants in JAM2

Penetrance

None

Publications

Panels with this gene

History Filter Activity

4 Mar 2026, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Lucy Jackson (NHS)

gene: JAM2 was added gene: JAM2 was added to Adult onset neurodegenerative disorder. Sources: Literature Mode of inheritance for gene: JAM2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: JAM2 were set to 31851307; 37446066 Phenotypes for gene: JAM2 were set to Basal ganglia calcification 7, 618317; Primary familial brain calcification; Fahr syndrome Review for gene: JAM2 was set to GREEN

Adult onset neurodegenerative disorder Gene: JAM2