Inherited pancreatic cancer
Gene: ATMEnsemblGeneIds (GRCh38): ENSG00000149311
EnsemblGeneIds (GRCh37): ENSG00000149311
OMIM: 607585, Gene2Phenotype
ATM is in 32 panels
3 reviews
Achchuthan Shanmugasundram (Genomics England Curator)
The rating of this gene has been updated to green and the mode of inheritance set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted following NHS Genomic Medicine Service approval.Created: 5 Dec 2024, 10:15 p.m. | Last Modified: 5 Dec 2024, 10:15 p.m.
Panel Version: 2.9
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sarah Leigh (Genomics England Curator)
ATM should be rated as green, based on the consensus reached at UKCGG/Cancer Leads meeting 29th February 2024.Created: 4 Jun 2024, 2:35 p.m. | Last Modified: 4 Jun 2024, 2:35 p.m.
Panel Version: 2.4
Terri McVeigh (Royal Marsden NHS Foundation Trust)
Discussed at UKCGG/Cancer Leads meeting 29th February 2024 - consensus that ATM should be added to this panel for diagnostic testing in individuals with pancreatic cancer fulfilling eligibility criteria. Reporting of variants should be restricted to truncating variants, high-risk missense c.7271T/G and exceptional variants as determined by Can-VIG UK, as per other panels where ATM is tested for cancer predisposition (R208/430)
Sources: OtherCreated: 22 May 2024, 8:30 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Breast, prostate, pancreatic cancer predisposition; recessive trait for ataxia telangiectasia
Publications
Mode of pathogenicity
Other
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- NHS GMS
- Phenotypes
-
- Breast, prostate, pancreatic cancer predisposition
- recessive trait for ataxia telangiectasia
- OMIM
- 607585
- Clinvar variants
- Variants in ATM
- Penetrance
- Incomplete
- Publications
- Mode of Pathogenicity
- Other
- Panels with this gene
-
- Hereditary haemorrhagic telangiectasia
- Intellectual disability
- Familial breast cancer
- Inherited prostate cancer
- Hereditary neuropathy
- Primary immunodeficiency or monogenic inflammatory bowel disease
- Brain cancer pertinent cancer susceptibility
- Primary ovarian insufficiency
- Haematological malignancies cancer susceptibility
- Inherited pancreatic cancer
- COVID-19 research
- Adult onset neurodegenerative disorder
- Haematological malignancies for rare disease
- Hereditary ataxia with onset in adulthood
- Hereditary neuropathy or pain disorder
- Ataxia telangiectasia - mutation testing
- Hereditary ataxia
- Fetal anomalies
- Childhood solid tumours cancer susceptibility
- Childhood onset dystonia, chorea or related movement disorder
- Inherited breast cancer and ovarian cancer
- Adult onset dystonia, chorea or related movement disorder
- Vascular skin disorders
- Familial Tumours Syndromes of the central & peripheral Nervous system
- DDG2P
- Adult solid tumours for rare disease
- Sarcoma susceptibility
- Early onset dystonia
- Ataxia and cerebellar anomalies - narrow panel
- Childhood solid tumours
- Adult solid tumours cancer susceptibility
- Inherited ovarian cancer (without breast cancer)
History Filter Activity
Removed Tag, Removed Tag, Removed Tag
Achchuthan Shanmugasundram (Genomics England Curator)Tag Q2_24_promote_green was removed from gene: ATM. Tag Q2_24_MOI was removed from gene: ATM. Tag Q2_24_NHS_review was removed from gene: ATM.
Added New Source, Added New Source, Status Update
Achchuthan Shanmugasundram (Genomics England Curator)Source NHS GMS was added to ATM. Source Expert Review Green was added to ATM. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Added Tag, Added Tag, Added Tag
Sarah Leigh (Genomics England Curator)Tag Q2_24_promote_green tag was added to gene: ATM. Tag Q2_24_MOI tag was added to gene: ATM. Tag Q2_24_NHS_review tag was added to gene: ATM.
Entity classified by Genomics England curator
Sarah Leigh (Genomics England Curator)Gene: atm has been classified as Amber List (Moderate Evidence).
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set penetrance, Set mode of pathogenicity
Terri McVeigh (Royal Marsden NHS Foundation Trust)gene: ATM was added gene: ATM was added to Inherited pancreatic cancer. Sources: Other Mode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: ATM were set to 34529012; 33509806 Phenotypes for gene: ATM were set to Breast, prostate, pancreatic cancer predisposition; recessive trait for ataxia telangiectasia Penetrance for gene: ATM were set to Incomplete Mode of pathogenicity for gene: ATM was set to Other Review for gene: ATM was set to GREEN