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Laterality disorders and isomerism

Gene: NME8

Red List (low evidence)
NME8 (NME/NM23 family member 8)
EnsemblGeneIds (GRCh38): ENSG00000086288
EnsemblGeneIds (GRCh37): ENSG00000086288
OMIM: 607421, Gene2Phenotype
NME8 is in 9 panels

2 reviews

Anna de Burca (Oxford University Hospitals NHS Foundation Trust)

Red List (low evidence)

No further cases reported since 2015. Discussed with NHS GMS respiratory specialist group including Hannah Mitchison 18/01/19, decision made to downgrade to red.
Created: 18 Jan 2019, 9:48 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Publications

Created: 18 Jan 2019, 9:48 p.m.

Panel version: 0.10

Louise Daugherty (Genomics England Curator)

Green List (high evidence)

Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: NME8; Suggested initial gene rating: Green; Evidence for inclusion: OMIM PCD or Visceral heterotaxy gene; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given
Created: 5 Dec 2018, 12:52 p.m.
Created: 5 Dec 2018, 12:52 p.m.

Panel version: 0.2

History Filter Activity

27 Nov 2019, Gel status: 1

Set mode of inheritance

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene: NME8 was changed from to BIALLELIC, autosomal or pseudoautosomal

27 Nov 2019, Gel status: 1

Set publications

Louise Daugherty (Genomics England Curator)

Publications for gene: NME8 were set to

18 Jan 2019, Gel status: 1

Entity classified by Genomics England curator

Anna de Burca (Oxford University Hospitals NHS Foundation Trust)

Gene: nme8 has been classified as Red List (Low Evidence).

5 Dec 2018, Gel status: 3

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Green was added to NME8. Rating Changed from Red List (low evidence) to Green List (high evidence)

5 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: NME8 was added gene: NME8 was added to Laterality disorders and isomerism. Sources: NHS GMS Mode of inheritance for gene: NME8 was set to