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Laterality disorders and isomerism

Gene: TTC25

Green List (high evidence)
TTC25 (tetratricopeptide repeat domain 25)
EnsemblGeneIds (GRCh38): ENSG00000204815
EnsemblGeneIds (GRCh37): ENSG00000204815
OMIM: 617095, Gene2Phenotype
TTC25 is in 4 panels

5 reviews

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

The rating of this gene has been updated to Green following NHS Genomic Medicine Service approval.
Created: 31 Jan 2023, 1:07 p.m. | Last Modified: 31 Jan 2023, 1:07 p.m.
Panel Version: 2.3
Created: 31 Jan 2023, 1:07 p.m.
Last Modified: 31 Jan 2023, 1:07 p.m.
Panel version: 2.3

Arina Puzriakova (Genomics England Curator)

Comment on list classification: Biallelic variants cause a primary ciliary dyskinesia which is associated with laterality defects - at least 6 unrelated families reported in literature (PMID: 27486780; 33715250; 33746037; 34215651)
This evidence now supports a Green rating on this panel and so this gene should be updated accordingly at the next GMS panel update.
Created: 13 Jul 2022, 3:47 p.m. | Last Modified: 13 Jul 2022, 3:47 p.m.
Panel Version: 1.48
Created: 13 Jul 2022, 3:47 p.m.
Last Modified: 13 Jul 2022, 3:47 p.m.
Panel version: 1.48

Catherine Snow (Genomics England)

Added new-gene-name tag, new approved HGNC gene symbol for TTC25 is ODAD4
Created: 24 Feb 2021, 5:11 p.m. | Last Modified: 24 Feb 2021, 5:11 p.m.
Panel Version: 1.21
Created: 24 Feb 2021, 5:11 p.m.
Last Modified: 24 Feb 2021, 5:11 p.m.
Panel version: 1.21

Matthew Edwards (Clinical Genetics & Genomics Lab, Royal Brompton & Harefield NHS Trust)

I don't know

Currently on CGGL Royal Brompton panel. Good but very limited published evidence.
Created: 25 Nov 2019, 11:25 p.m. | Last Modified: 25 Nov 2019, 11:25 p.m.
Panel Version: 0.51

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
OMIM 617092 Ciliary dyskinesia, primary, 35

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 25 Nov 2019, 11:25 p.m.
Last Modified: 25 Nov 2019, 11:25 p.m.
Panel version: 0.51

Louise Daugherty (Genomics England Curator)

Green List (high evidence)

Comment on list classification: Downgraded from Green to Amber after expert review. Change of rating will be included in update with Test Group to enable further comment/review if required before sign off.
Created: 27 Nov 2019, 1:11 p.m. | Last Modified: 27 Nov 2019, 1:11 p.m.
Panel Version: 0.135
From GMS Respiratory Specialist Test Group webex call 18th Jan 2019 : there are unpublished cases and functional evidence to support this gene to be rated as Green.
Created: 21 Jan 2019, 4:51 p.m.
Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: TTC25; Suggested initial gene rating: Green; Evidence for inclusion: OMIM PCD or Visceral heterotaxy gene; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given
Created: 5 Dec 2018, 12:52 p.m.
Created: 5 Dec 2018, 12:52 p.m.

Panel version: 0.20

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • NHS GMS
Phenotypes
  • Ciliary dyskinesia, primary, 35, OMIM:617092
Tags
new-gene-name
OMIM
617095
Clinvar variants
Variants in TTC25
Penetrance
None
Publications
Panels with this gene

History Filter Activity

31 Jan 2023, Gel status: 3

Removed Tag

Sarah Leigh (Genomics England Curator)

Tag Q3_22_rating was removed from gene: TTC25.

31 Jan 2023, Gel status: 3

Added New Source, Status Update

Sarah Leigh (Genomics England Curator)

Source Expert Review Green was added to TTC25. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)

13 Jul 2022, Gel status: 2

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: TTC25 were changed from Ciliary dyskinesia, primary, 35, 617092 to Ciliary dyskinesia, primary, 35, OMIM:617092

13 Jul 2022, Gel status: 2

Set publications

Arina Puzriakova (Genomics England Curator)

Publications for gene: TTC25 were set to 27486780

13 Jul 2022, Gel status: 2

Entity classified by Genomics England curator

Arina Puzriakova (Genomics England Curator)

Gene: ttc25 has been classified as Amber List (Moderate Evidence).

13 Jul 2022, Gel status: 2

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag Q3_22_rating tag was added to gene: TTC25.

24 Feb 2021, Gel status: 2

Added Tag

Catherine Snow (Genomics England)

Tag new-gene-name tag was added to gene: TTC25.

27 Nov 2019, Gel status: 2

Entity classified by Genomics England curator

Louise Daugherty (Genomics England Curator)

Gene: ttc25 has been classified as Amber List (Moderate Evidence).

27 Nov 2019, Gel status: 3

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Phenotypes for gene: TTC25 were changed from to Ciliary dyskinesia, primary, 35, 617092

27 Nov 2019, Gel status: 3

Set publications

Louise Daugherty (Genomics England Curator)

Publications for gene: TTC25 were set to

27 Nov 2019, Gel status: 3

Set mode of inheritance

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene: TTC25 was changed from to BIALLELIC, autosomal or pseudoautosomal

5 Dec 2018, Gel status: 3

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Green was added to TTC25. Rating Changed from Red List (low evidence) to Green List (high evidence)

5 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: TTC25 was added gene: TTC25 was added to Laterality disorders and isomerism. Sources: NHS GMS Mode of inheritance for gene: TTC25 was set to