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Sarcoma susceptibility

Gene: T

Green List (high evidence)
T (T brachyury transcription factor)
EnsemblGeneIds (GRCh38): ENSG00000164458
EnsemblGeneIds (GRCh37): ENSG00000164458
OMIM: 601397, Gene2Phenotype
T is in 6 panels

4 reviews

Arina Puzriakova (Genomics England Curator)

Added new-gene-name tag, new approved HGNC gene symbol is TBXT
Created: 10 May 2022, 3:20 p.m. | Last Modified: 10 May 2022, 3:20 p.m.
Panel Version: 1.69
Comment on phenotypes: This gene is also associated with {Neural tube defects, susceptibility to}, OMIM:182940; Sacral agenesis with vertebral anomalies, OMIM:615709
Created: 11 Mar 2021, 10:24 a.m. | Last Modified: 11 Mar 2021, 10:24 a.m.
Panel Version: 1.18
Created: 11 Mar 2021, 10:24 a.m.
Last Modified: 11 Mar 2021, 10:24 a.m.
Panel version: 1.69

Rebecca Foulger (Genomics England curator)

Green List (high evidence)

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: agreed that there is enough evidence to rate this gene green.
Created: 23 Jul 2019, 3:16 p.m. | Last Modified: 23 Jul 2019, 3:16 p.m.
Panel Version: 0.2
Created: 23 Jul 2019, 3:16 p.m.
Last Modified: 23 Jul 2019, 3:16 p.m.
Panel version: 0.2

Louise Daugherty (Genomics England Curator)

Added new-gene-name tag, new approved HGNC gene symbol is TBXT
Created: 25 May 2018, 8:47 a.m.
Created: 25 May 2018, 8:47 a.m.

Panel version: Imported from Sarcoma cancer susceptibility panel version 0.34

Ellen McDonagh (Genomics England Curator)

This gene was reviewed by Lara Hawkes (Cancer Clinical Team, Genomics England) and agrees this should be included on this panel.
Created: 20 Aug 2018, 1:30 p.m.
Gene and evidence provided by Adrienne Flanagan, UCL.
Created: 14 May 2018, 4:01 p.m.
Created: 14 May 2018, 4:01 p.m.

Panel version: Imported from Sarcoma cancer susceptibility panel version 0.35

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • NHS GMS
  • Expert Review Green
  • Expert list
Phenotypes
  • Chordoma (disease), MONDO:0008978
Tags
new-gene-name
OMIM
601397
Clinvar variants
Variants in T
Penetrance
None
Publications
Panels with this gene

History Filter Activity

22 Jan 2024, Gel status: 3

Set publications

Arina Puzriakova (Genomics England Curator)

Publications for gene: T were set to 23064415; 19801981; 34837714

22 Jan 2024, Gel status: 3

Set publications

Arina Puzriakova (Genomics England Curator)

Publications for gene: T were set to 23064415; 19801981

10 May 2022, Gel status: 3

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag new-gene-name tag was added to gene: T.

12 Mar 2021, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: T were changed from Susceptibility to Chordoma; Chordoma (disease), MONDO:0008978 to Chordoma (disease), MONDO:0008978

11 Mar 2021, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: T were changed from Familial Chordoma; Chordoma to Susceptibility to Chordoma; Chordoma (disease), MONDO:0008978

23 Jul 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: T was added gene: T was added to Sarcoma susceptibility. Sources: NHS GMS,Expert Review Green Mode of inheritance for gene: T was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: T were set to 23064415; 19801981 Phenotypes for gene: T were set to Familial Chordoma; Chordoma