Sarcoma susceptibility
Gene: TNFRSF11A

TNFRSF11A (TNF receptor superfamily member 11a)
EnsemblGeneIds (GRCh38): ENSG00000141655
EnsemblGeneIds (GRCh37): ENSG00000141655
OMIM: 603499, Gene2Phenotype
TNFRSF11A is in 10 panels

1 review

Ellen McDonagh (Genomics England Curator)

Gene and evidence provided by Adrienne Flanagan, UCL. Comment from Adrienne on the evidence for this gene: "TNFRSF11A is linked to familial Pagetic bone disease and Pagetic bone disease is associated with sarcoma…although the body of evidence linking TNFRSF11A and osteosarcoma is limited."
Created: 14 May 2018, 3:49 p.m.

Created: 14 May 2018, 3:49 p.m.

Panel version: Imported from Sarcoma cancer susceptibility panel version 0.27

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

NHS GMS
Expert Review Red
Expert Review Red
Expert list

Phenotypes

{Paget disease of bone 2, early-onset}, OMIM:602080
Osteosarcoma (disease), MONDO:0009807

OMIM

603499

Clinvar variants

Variants in TNFRSF11A

Penetrance

None

Publications

Panels with this gene

History Filter Activity

12 Mar 2021, Gel status: 1

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: TNFRSF11A were changed from Paget disease of bone; Polyostotic osteolytic dysplasia (hereditary expansile); Osteosarcoma to {Paget disease of bone 2, early-onset}, OMIM:602080; Osteosarcoma (disease), MONDO:0009807

1 Aug 2019, Gel status: 1

Added New Source

Rebecca Foulger (Genomics England curator)

Source NHS GMS was added to TNFRSF11A.

23 Jul 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes