Hypogonadotropic hypogonadism
Gene: GNRH1
Comment when marking as ready: Associated with phenotype in OMIM, not in G2P. Found in 3/4 sources. At least variants reported. Two expert reviewers recommend GreenCreated: 13 Oct 2016, 8:13 a.m.
28th Oct 2016: This panel was revised after external expert review and internal discussion. For several genes that have been shown to contribute to the disorder in a digenic/polygenic manner, the decision was made to only include genes as green if biallelic variants had been reported independently from other genes. Genes with a monoallelic mechanism, that have been shown in some studies in conjunction with variants in other genes, were made red as monoallelic variants in these genes may not provide a complete diagnosis.
Publications for GNRH1 were set to 26595427; 23936060; 22724017
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
GNRH1 was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: Illumina TruGenome Clinical Sequencing Services
GNRH1 was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: Radboud University Medical Center, Nijmegen
GNRH1 was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: Emory Genetics Laboratory
GNRH1 was created by sleigh
GNRH1 was added to Idiopathic hypogonadotropic hypogonadismpanel. Sources: OMIM