Hypogonadotropic hypogonadism
Gene: PROP1
Comment when marking as ready: Associated with phenotype in OMIM and G2P. Found in 2/4 sources. At least 13 variants reported. Three reviewers recommend GreenCreated: 13 Oct 2016, 9:26 a.m.
Associated with hypogonadotrophic hypogonadism as well as combined pituitary hormone deficiencies.Created: 24 May 2016, 12:18 p.m.
28th Oct 2016: This panel was revised after external expert review and internal discussion. For several genes that have been shown to contribute to the disorder in a digenic/polygenic manner, the decision was made to only include genes as green if biallelic variants had been reported independently from other genes. Genes with a monoallelic mechanism, that have been shown in some studies in conjunction with variants in other genes, were made red as monoallelic variants in these genes may not provide a complete diagnosis.
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
PROP1 was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: Illumina TruGenome Clinical Sequencing Services
PROP1 was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: Emory Genetics Laboratory
PROP1 was added to Idiopathic hypogonadotropic hypogonadismpanel. Sources: UKGTN
PROP1 was created by sleigh