Hypogonadotropic hypogonadism
Gene: TAC3Comment when marking as ready: Associated with phenotype in OMIM and G2P. Found in 2/4 sources. Two variants reported, each in a family from different populations (Turkish and Asian). Segregation and in vitro studies support involvement in phenotype, plus no variants found in 100 Turkish controls. Three expert reviewers recommend GreenCreated: 13 Oct 2016, 2:28 p.m.
28th Oct 2016: This panel was revised after external expert review and internal discussion. For several genes that have been shown to contribute to the disorder in a digenic/polygenic manner, the decision was made to only include genes as green if biallelic variants had been reported independently from other genes. Genes with a monoallelic mechanism, that have been shown in some studies in conjunction with variants in other genes, were made red as monoallelic variants in these genes may not provide a complete diagnosis.
Publications for TAC3 were set to 19079066; 20332248
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
TAC3 was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: Radboud University Medical Center, Nijmegen
TAC3 was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: Emory Genetics Laboratory
TAC3 was created by sleigh
TAC3 was added to Idiopathic hypogonadotropic hypogonadismpanel. Sources: OMIM