Hypogonadotropic hypogonadismGene: LHB
Comment when marking as ready: Associated with phenotype in OMIM, not in G2P. Found in 1/4 sources. At least six variants reported as homozygotes or compound heterozygotes. Two reviewers recommend Green
Created: 13 Oct 2016, 8:41 a.m.
28th Oct 2016: This panel was revised after external expert review and internal discussion. For several genes that have been shown to contribute to the disorder in a digenic/polygenic manner, the decision was made to only include genes as green if biallelic variants had been reported independently from other genes. Genes with a monoallelic mechanism, that have been shown in some studies in conjunction with variants in other genes, were made red as monoallelic variants in these genes may not provide a complete diagnosis.
This gene has been classified as Green List (High Evidence).
This gene has been classified as Red List (Low Evidence).
Phenotypes for gene LHB were set to Hypogonadotropic hypogonadism 23 with or without anosmia, 228300
LHB was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: OMIM
LHB was created by sleigh
LHB was added to Idiopathic hypogonadotropic hypogonadismpanel. Sources: Radboud University Medical Center, Nijmegen