Hypogonadotropic hypogonadism
Gene: WDR11Comment when marking as ready: Associated with phenotype in OMIM and G2P. Found in 1/4 sources. Three reviewers recommend Green. Literature report 5 variants, including three alterations (A435T, R448Q, and H690Q) in WD domains important for β propeller formation and protein-protein interactionCreated: 26 May 2016, 2:31 p.m.
28th Oct 2016: This panel was revised after external expert review and internal discussion. For several genes that have been shown to contribute to the disorder in a digenic/polygenic manner, the decision was made to only include genes as green if biallelic variants had been reported independently from other genes. Genes with a monoallelic mechanism, that have been shown in some studies in conjunction with variants in other genes, were made red as monoallelic variants in these genes may not provide a complete diagnosis.
Publications for WDR11 were set to 21856375; 20887964; 25064402
Phenotypes for gene WDR11 were set to Hypogonadotropic hypogonadism 14 with or without anosmia, 614858
Publications for WDR11 were set to 21856375; 20887964; 25064402
This gene has been classified as Green List (High Evidence).
WDR11 was added to Idiopathic hypogonadotropic hypogonadismpanel. Sources: Literature
This gene has been classified as Green List (High Evidence).
Publications for WDR11 were set to 21856375; 20887964
Publications for WDR11 were set to 21856375;
WDR11 was added to Idiopathic hypogonadotropic hypogonadismpanel. Source: Radboud University Medical Center, Nijmegen
WDR11 was added to Idiopathic hypogonadotropic hypogonadismpanel. Sources: OMIM
WDR11 was created by sleigh