Viral resistance

Gene: SELPLG

Red List (low evidence)

PMID: 30833724 identifies SELPLG (refered to as PSGL1 in the literature) as an HIV restriction factor, SELPLG is induced by interferon-γ in activated CD4+ T cells to inhibit HIV-1 reverse transcription and potently block viral infectivity by incorporating in progeny virions.
Preprint https://doi.org/10.1101/2020.05.01.073387 report that virion incorporation of SELPLG on SARS-CoV and SARS-CoV-2 pseudovirions blocks S protein-mediated virus attachment and infection of target cells, Suggesting that SELPLG-imprinted non-infectious viral particles could serve as a live attenuated vaccine for SARS-CoV-2 infection.

In PMID 19543284 SELPLG (refered to as PSGL1 in the literature) is a receptor for 5 of 8 the Enterovirus-71 (EV71) strains. EV71 interaction and viral replication could be inhibited by monoclonal antibodies to SELPLG. The authors concluded that SELPLG-positive leukocytes are involved in the cell tropism and pathogenesis of hand, foot and mouth disease and other EV71-mediated diseases.
Sources: Literature

Created: 12 May 2020, 8:21 a.m.

Mode of inheritance
Unknown

Publications

• 19543284
• 30833724
• doi.org/10.1101/2020.05.01.073387