BRIDGE_SPEED_NEURO_v2.0_20160416
Gene: KRAS

KRAS (KRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000133703
EnsemblGeneIds (GRCh37): ENSG00000133703
OMIM: 190070, Gene2Phenotype
KRAS is in 30 panels

1 review

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

ddg2p_20141118; ddg2p_20141118_conf; ddg2p_201507; ddg2p_201507_conf; find_uk10k; gilissen_2014_known; UKGTN_v12; Nijmegen_ID_diagnostic; Nijmegen_ID_candidates; GEL_ID_green_20160217; neuro_20160418_strict; Activating
Created: 7 Feb 2017, 4:33 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Lung cancer, somatic, 211980; Bladder cancer, somatic, 109800; Pancreatic carcinoma, somatic, 260350; Gastric cancer, somatic, 137215; Leukemia, acute myelogenous; Noonan syndrome 3, 609942; Cardiofaciocutaneous syndrome 2, 615278; Breast cancer, somatic, 114480; SFM syndrome, somatic mosaic, 163200

Mode of pathogenicity
Other - please provide details in the comments

Variants in this GENE are reported as part of current diagnostic practice

Created: 7 Feb 2017, 4:33 p.m.

Panel version: 0.2

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

BRIDGE

Phenotypes

Lung cancer, somatic, 211980
Bladder cancer, somatic, 109800
Pancreatic carcinoma, somatic, 260350
Gastric cancer, somatic, 137215
Leukemia, acute myelogenous
Noonan syndrome 3, 609942
Cardiofaciocutaneous syndrome 2, 615278
Breast cancer, somatic, 114480
SFM syndrome, somatic mosaic, 163200

OMIM

190070

Clinvar variants

Variants in KRAS

Penetrance

Complete

Panels with this gene

History Filter Activity

7 Feb 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

KRAS was created by ellenmcdonagh

7 Feb 2017, Gel status: 0

Added New Source