07 Nov 2023
Inherited non-medullary thyroid cancer v1.7
SEC23B
Arina Puzriakova Classified gene: SEC23B as Red List (low evidence)
07 Nov 2023
Inherited non-medullary thyroid cancer v1.7
SEC23B
Arina Puzriakova Added comment: Comment on list classification: There is limited evidence linking this gene with Cowden syndrome (monoallelic variants). Only one family has been reported to date (PMID:26522472). The other variant identified in 2 unrelated women discussed in previous reviews, has since been reclassified as a VUS. This gene:disease association is provisional in OMIM, 'limited' disease confidence category in G2P and is not listed in ClinGen (whereas CDAII is). On this basis, downgrading the rating of this gene from Green to Red.
07 Nov 2023
Inherited non-medullary thyroid cancer v1.7
SEC23B
Arina Puzriakova Gene: sec23b has been classified as Red List (Low Evidence).
07 Nov 2023
Inherited non-medullary thyroid cancer v1.6
SEC23B
Arina Puzriakova Phenotypes for gene: SEC23B were changed from Cowden syndrome 7 616858 to Cowden syndrome 7, OMIM:616858
02 Dec 2020
Inherited non-medullary thyroid cancer v1.5
DICER1
Arina Puzriakova Phenotypes for gene: DICER1 were changed from Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors 138800; Pleuropulmonary blastoma 601200 to Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors, OMIM:138800
17 Nov 2020
Inherited non-medullary thyroid cancer v1.4
VTRNA2-1
Sarah Leigh Tag locus-type-rna-vault tag was added to gene: VTRNA2-1.
08 Jul 2020
Inherited non-medullary thyroid cancer v1.4
PTCSC1
Eleanor Williams Tag ensembl_ids_known_missing tag was added to gene: PTCSC1.
08 Jul 2020
Inherited non-medullary thyroid cancer v1.4
PTCSC1
Eleanor Williams commented on gene: PTCSC1
07 Aug 2017
Inherited non-medullary thyroid cancer
Sarah Leigh promoted panel to version 1
07 Aug 2017
Inherited non-medullary thyroid cancer
SDHD
Sarah Leigh added SDHD to panel
07 Aug 2017
Inherited non-medullary thyroid cancer
SDHD
Sarah Leigh reviewed SDHD
07 Aug 2017
Inherited non-medullary thyroid cancer
SEC23B
Sarah Leigh marked SEC23B as ready
07 Aug 2017
Inherited non-medullary thyroid cancer
SEC23B
Sarah Leigh commented on SEC23B
07 Aug 2017
Inherited non-medullary thyroid cancer
VTRNA2-1
Sarah Leigh reviewed VTRNA2-1
07 Aug 2017
Inherited non-medullary thyroid cancer
SEC23B
Sarah Leigh classified SEC23B as green
07 Aug 2017
Inherited non-medullary thyroid cancer
PTCSC1
Sarah Leigh marked PTCSC1 as ready
07 Aug 2017
Inherited non-medullary thyroid cancer
PTCSC1
Sarah Leigh commented on PTCSC1
07 Aug 2017
Inherited non-medullary thyroid cancer
PIK3CA
Sarah Leigh marked PIK3CA as ready
07 Aug 2017
Inherited non-medullary thyroid cancer
PIK3CA
Sarah Leigh commented on PIK3CA
07 Aug 2017
Inherited non-medullary thyroid cancer
NKX2-1
Sarah Leigh marked NKX2-1 as ready
07 Aug 2017
Inherited non-medullary thyroid cancer
NKX2-1
Sarah Leigh commented on NKX2-1
07 Aug 2017
Inherited non-medullary thyroid cancer
NDUFA13
Sarah Leigh marked NDUFA13 as ready
07 Aug 2017
Inherited non-medullary thyroid cancer
NDUFA13
Sarah Leigh commented on NDUFA13
07 Aug 2017
Inherited non-medullary thyroid cancer
MSH2
Sarah Leigh marked MSH2 as ready
07 Aug 2017
Inherited non-medullary thyroid cancer
MSH2
Sarah Leigh classified MSH2 as amber
07 Aug 2017
Inherited non-medullary thyroid cancer
MINPP1
Sarah Leigh reviewed MINPP1
07 Aug 2017
Inherited non-medullary thyroid cancer
KISS1R
Sarah Leigh marked KISS1R as ready
07 Aug 2017
Inherited non-medullary thyroid cancer
KISS1R
Sarah Leigh commented on KISS1R
07 Aug 2017
Inherited non-medullary thyroid cancer
HABP2
Sarah Leigh marked HABP2 as ready
07 Aug 2017
Inherited non-medullary thyroid cancer
HABP2
Sarah Leigh commented on HABP2
01 Aug 2017
Inherited non-medullary thyroid cancer
GNAS
Sarah Leigh marked GNAS as ready
31 Jul 2017
Inherited non-medullary thyroid cancer
FOXE1
Sarah Leigh marked FOXE1 as ready
31 Jul 2017
Inherited non-medullary thyroid cancer
FOXE1
Sarah Leigh classified FOXE1 as amber
31 Jul 2017
Inherited non-medullary thyroid cancer
FOXE1
Sarah Leigh commented on FOXE1
31 Jul 2017
Inherited non-medullary thyroid cancer
DIRAS3
Sarah Leigh marked DIRAS3 as ready
31 Jul 2017
Inherited non-medullary thyroid cancer
DIRAS3
Sarah Leigh commented on DIRAS3
31 Jul 2017
Inherited non-medullary thyroid cancer
DICER1
Sarah Leigh marked DICER1 as ready
31 Jul 2017
Inherited non-medullary thyroid cancer
DICER1
Sarah Leigh classified DICER1 as green
31 Jul 2017
Inherited non-medullary thyroid cancer
DICER1
Sarah Leigh commented on DICER1
31 Jul 2017
Inherited non-medullary thyroid cancer
BRAF
Sarah Leigh marked BRAF as ready
10 Jul 2017
Inherited non-medullary thyroid cancer
WRN
Sarah Leigh marked WRN as ready
10 Jul 2017
Inherited non-medullary thyroid cancer
SLC5A5
Sarah Leigh marked SLC5A5 as ready
10 Jul 2017
Inherited non-medullary thyroid cancer
SLC5A5
Sarah Leigh commented on SLC5A5
10 Jul 2017
Inherited non-medullary thyroid cancer
TG
Sarah Leigh marked TG as ready
10 Jul 2017
Inherited non-medullary thyroid cancer
TG
Sarah Leigh commented on TG
10 Jul 2017
Inherited non-medullary thyroid cancer
TG
Sarah Leigh classified TG as red
10 Jul 2017
Inherited non-medullary thyroid cancer
PTEN
Sarah Leigh marked PTEN as ready
10 Jul 2017
Inherited non-medullary thyroid cancer
PTEN
Sarah Leigh commented on PTEN
27 Jun 2017
Inherited non-medullary thyroid cancer
PRKAR1A
Sarah Leigh marked PRKAR1A as ready
27 Jun 2017
Inherited non-medullary thyroid cancer
PRKAR1A
Sarah Leigh commented on PRKAR1A
26 Jun 2017
Inherited non-medullary thyroid cancer
SRRM2
Sarah Leigh marked SRRM2 as ready
26 Jun 2017
Inherited non-medullary thyroid cancer
SRRM2
Sarah Leigh commented on SRRM2
26 Jun 2017
Inherited non-medullary thyroid cancer
SRRM2
Sarah Leigh classified SRRM2 as red
26 Jun 2017
Inherited non-medullary thyroid cancer
SDHB
Sarah Leigh marked SDHB as ready
26 Jun 2017
Inherited non-medullary thyroid cancer
SDHB
Sarah Leigh classified SDHB as red
26 Jun 2017
Inherited non-medullary thyroid cancer
SDHB
Sarah Leigh edited their review of SDHB
26 Jun 2017
Inherited non-medullary thyroid cancer
SDHB
Sarah Leigh commented on SDHB
26 Jun 2017
Inherited non-medullary thyroid cancer
GNAS
Sarah Leigh commented on GNAS
26 Jun 2017
Inherited non-medullary thyroid cancer
GNAS
Sarah Leigh added GNAS to panel
26 Jun 2017
Inherited non-medullary thyroid cancer
GNAS
Sarah Leigh reviewed GNAS
26 Jun 2017
Inherited non-medullary thyroid cancer
BRCA2
Sarah Leigh added BRCA2 to panel
26 Jun 2017
Inherited non-medullary thyroid cancer
BRCA2
Sarah Leigh reviewed BRCA2
26 Jun 2017
Inherited non-medullary thyroid cancer
BRCA1
Sarah Leigh added BRCA1 to panel
26 Jun 2017
Inherited non-medullary thyroid cancer
BRCA1
Sarah Leigh reviewed BRCA1
26 Jun 2017
Inherited non-medullary thyroid cancer
MSH6
Sarah Leigh classified MSH6 as red
23 Jun 2017
Inherited non-medullary thyroid cancer
DICER1
Ellen McDonagh reviewed DICER1
22 Jun 2017
Inherited non-medullary thyroid cancer
MEN1
Sarah Leigh added MEN1 to panel
22 Jun 2017
Inherited non-medullary thyroid cancer
MEN1
Sarah Leigh reviewed MEN1
21 Jun 2017
Inherited non-medullary thyroid cancer
MSH2
Sarah Leigh added MSH2 to panel
21 Jun 2017
Inherited non-medullary thyroid cancer
MSH2
Sarah Leigh reviewed MSH2
21 Jun 2017
Inherited non-medullary thyroid cancer
MSH6
Sarah Leigh added MSH6 to panel
21 Jun 2017
Inherited non-medullary thyroid cancer
MSH6
Sarah Leigh reviewed MSH6
21 Jun 2017
Inherited non-medullary thyroid cancer
BRAF
Sarah Leigh added BRAF to panel
21 Jun 2017
Inherited non-medullary thyroid cancer
BRAF
Sarah Leigh reviewed BRAF
21 Jun 2017
Inherited non-medullary thyroid cancer
APC
Sarah Leigh marked APC as ready
21 Jun 2017
Inherited non-medullary thyroid cancer
APC
Sarah Leigh commented on APC
13 Jun 2017
Inherited non-medullary thyroid cancer
SDHB
Emma Woodward added SDHB to panel
13 Jun 2017
Inherited non-medullary thyroid cancer
SDHB
Emma Woodward reviewed SDHB
13 Jun 2017
Inherited non-medullary thyroid cancer
SRRM2
Emma Woodward added SRRM2 to panel
13 Jun 2017
Inherited non-medullary thyroid cancer
SRRM2
Emma Woodward reviewed SRRM2
13 Jun 2017
Inherited non-medullary thyroid cancer
VTRNA2-1
Emma Woodward reviewed VTRNA2-1
13 Jun 2017
Inherited non-medullary thyroid cancer
SRGAP1
Emma Woodward reviewed SRGAP1
13 Jun 2017
Inherited non-medullary thyroid cancer
SEC23B
Emma Woodward reviewed SEC23B
13 Jun 2017
Inherited non-medullary thyroid cancer
PTCSC3
Emma Woodward reviewed PTCSC3
13 Jun 2017
Inherited non-medullary thyroid cancer
PTCSC1
Emma Woodward reviewed PTCSC1
13 Jun 2017
Inherited non-medullary thyroid cancer
PIK3CA
Emma Woodward reviewed PIK3CA
13 Jun 2017
Inherited non-medullary thyroid cancer
NKX2-1
Emma Woodward reviewed NKX2-1
13 Jun 2017
Inherited non-medullary thyroid cancer
NDUFA13
Emma Woodward commented on NDUFA13
13 Jun 2017
Inherited non-medullary thyroid cancer
MINPP1
Emma Woodward edited their review of MINPP1
13 Jun 2017
Inherited non-medullary thyroid cancer
MINPP1
Emma Woodward commented on MINPP1
13 Jun 2017
Inherited non-medullary thyroid cancer
KISS1R
Emma Woodward commented on KISS1R
13 Jun 2017
Inherited non-medullary thyroid cancer
HABP2
Emma Woodward reviewed HABP2
13 Jun 2017
Inherited non-medullary thyroid cancer
FOXE1
Emma Woodward commented on FOXE1
13 Jun 2017
Inherited non-medullary thyroid cancer
FOXE1
Emma Woodward reviewed FOXE1
13 Jun 2017
Inherited non-medullary thyroid cancer
DIRAS3
Emma Woodward reviewed DIRAS3
13 Jun 2017
Inherited non-medullary thyroid cancer
DICER1
Emma Woodward reviewed DICER1
13 Jun 2017
Inherited non-medullary thyroid cancer
SLC5A5
Emma Woodward reviewed SLC5A5
13 Jun 2017
Inherited non-medullary thyroid cancer
SLC5A5
Emma Woodward reviewed SLC5A5
13 Jun 2017
Inherited non-medullary thyroid cancer
WRN
Emma Woodward reviewed WRN
13 Jun 2017
Inherited non-medullary thyroid cancer
TG
Emma Woodward reviewed TG
13 Jun 2017
Inherited non-medullary thyroid cancer
PTEN
Emma Woodward reviewed PTEN
13 Jun 2017
Inherited non-medullary thyroid cancer
PRKAR1A
Emma Woodward reviewed PRKAR1A
13 Jun 2017
Inherited non-medullary thyroid cancer
APC
Emma Woodward reviewed APC
09 Jun 2017
Inherited non-medullary thyroid cancer
PIK3CA
Fiona Lalloo reviewed PIK3CA
09 Jun 2017
Inherited non-medullary thyroid cancer
PIK3CA
Fiona Lalloo commented on PIK3CA
09 Jun 2017
Inherited non-medullary thyroid cancer
NKX2-1
Fiona Lalloo reviewed NKX2-1
09 Jun 2017
Inherited non-medullary thyroid cancer
NDUFA13
Fiona Lalloo reviewed NDUFA13
09 Jun 2017
Inherited non-medullary thyroid cancer
MINPP1
Fiona Lalloo reviewed MINPP1
09 Jun 2017
Inherited non-medullary thyroid cancer
KISS1R
Fiona Lalloo commented on KISS1R
09 Jun 2017
Inherited non-medullary thyroid cancer
KISS1R
Fiona Lalloo reviewed KISS1R
09 Jun 2017
Inherited non-medullary thyroid cancer
HABP2
Fiona Lalloo reviewed HABP2
09 Jun 2017
Inherited non-medullary thyroid cancer
FOXE1
Fiona Lalloo reviewed FOXE1
09 Jun 2017
Inherited non-medullary thyroid cancer
DIRAS3
Fiona Lalloo reviewed DIRAS3
09 Jun 2017
Inherited non-medullary thyroid cancer
DICER1
Fiona Lalloo reviewed DICER1
09 Jun 2017
Inherited non-medullary thyroid cancer
SLC5A5
Fiona Lalloo reviewed SLC5A5
09 Jun 2017
Inherited non-medullary thyroid cancer
WRN
Fiona Lalloo reviewed WRN
09 Jun 2017
Inherited non-medullary thyroid cancer
TG
Fiona Lalloo reviewed TG
09 Jun 2017
Inherited non-medullary thyroid cancer
PTEN
Fiona Lalloo reviewed PTEN
09 Jun 2017
Inherited non-medullary thyroid cancer
PRKAR1A
Fiona Lalloo reviewed PRKAR1A
08 Jun 2017
Inherited non-medullary thyroid cancer
APC
Fiona Lalloo reviewed APC
18 May 2017
Inherited non-medullary thyroid cancer
WRN
Sarah Leigh edited their review of WRN
18 May 2017
Inherited non-medullary thyroid cancer
WRN
Sarah Leigh added WRN to panel
18 May 2017
Inherited non-medullary thyroid cancer
WRN
Sarah Leigh reviewed WRN