Activity

Filter

Cancel
Date Panel Item Activity
123 actions
Inherited non-medullary thyroid cancer v1.7 SEC23B Arina Puzriakova Classified gene: SEC23B as Red List (low evidence)
Inherited non-medullary thyroid cancer v1.7 SEC23B Arina Puzriakova Added comment: Comment on list classification: There is limited evidence linking this gene with Cowden syndrome (monoallelic variants). Only one family has been reported to date (PMID:26522472). The other variant identified in 2 unrelated women discussed in previous reviews, has since been reclassified as a VUS.

This gene:disease association is provisional in OMIM, 'limited' disease confidence category in G2P and is not listed in ClinGen (whereas CDAII is).

On this basis, downgrading the rating of this gene from Green to Red.
Inherited non-medullary thyroid cancer v1.7 SEC23B Arina Puzriakova Gene: sec23b has been classified as Red List (Low Evidence).
Inherited non-medullary thyroid cancer v1.6 SEC23B Arina Puzriakova Phenotypes for gene: SEC23B were changed from Cowden syndrome 7 616858 to Cowden syndrome 7, OMIM:616858
Inherited non-medullary thyroid cancer v1.5 DICER1 Arina Puzriakova Phenotypes for gene: DICER1 were changed from Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors 138800; Pleuropulmonary blastoma 601200 to Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors, OMIM:138800
Inherited non-medullary thyroid cancer v1.4 VTRNA2-1 Sarah Leigh Tag locus-type-rna-vault tag was added to gene: VTRNA2-1.
Inherited non-medullary thyroid cancer v1.4 PTCSC1 Eleanor Williams Tag ensembl_ids_known_missing tag was added to gene: PTCSC1.
Inherited non-medullary thyroid cancer v1.4 PTCSC1 Eleanor Williams commented on gene: PTCSC1
Inherited non-medullary thyroid cancer Sarah Leigh promoted panel to version 1
Inherited non-medullary thyroid cancer SDHD Sarah Leigh added SDHD to panel
Inherited non-medullary thyroid cancer SDHD Sarah Leigh reviewed SDHD
Inherited non-medullary thyroid cancer SEC23B Sarah Leigh marked SEC23B as ready
Inherited non-medullary thyroid cancer SEC23B Sarah Leigh commented on SEC23B
Inherited non-medullary thyroid cancer VTRNA2-1 Sarah Leigh reviewed VTRNA2-1
Inherited non-medullary thyroid cancer SEC23B Sarah Leigh classified SEC23B as green
Inherited non-medullary thyroid cancer PTCSC1 Sarah Leigh marked PTCSC1 as ready
Inherited non-medullary thyroid cancer PTCSC1 Sarah Leigh commented on PTCSC1
Inherited non-medullary thyroid cancer PIK3CA Sarah Leigh marked PIK3CA as ready
Inherited non-medullary thyroid cancer PIK3CA Sarah Leigh commented on PIK3CA
Inherited non-medullary thyroid cancer NKX2-1 Sarah Leigh marked NKX2-1 as ready
Inherited non-medullary thyroid cancer NKX2-1 Sarah Leigh commented on NKX2-1
Inherited non-medullary thyroid cancer NDUFA13 Sarah Leigh marked NDUFA13 as ready
Inherited non-medullary thyroid cancer NDUFA13 Sarah Leigh commented on NDUFA13
Inherited non-medullary thyroid cancer MSH2 Sarah Leigh marked MSH2 as ready
Inherited non-medullary thyroid cancer MSH2 Sarah Leigh classified MSH2 as amber
Inherited non-medullary thyroid cancer MINPP1 Sarah Leigh reviewed MINPP1
Inherited non-medullary thyroid cancer KISS1R Sarah Leigh marked KISS1R as ready
Inherited non-medullary thyroid cancer KISS1R Sarah Leigh commented on KISS1R
Inherited non-medullary thyroid cancer HABP2 Sarah Leigh marked HABP2 as ready
Inherited non-medullary thyroid cancer HABP2 Sarah Leigh commented on HABP2
Inherited non-medullary thyroid cancer GNAS Sarah Leigh marked GNAS as ready
Inherited non-medullary thyroid cancer FOXE1 Sarah Leigh marked FOXE1 as ready
Inherited non-medullary thyroid cancer FOXE1 Sarah Leigh classified FOXE1 as amber
Inherited non-medullary thyroid cancer FOXE1 Sarah Leigh commented on FOXE1
Inherited non-medullary thyroid cancer DIRAS3 Sarah Leigh marked DIRAS3 as ready
Inherited non-medullary thyroid cancer DIRAS3 Sarah Leigh commented on DIRAS3
Inherited non-medullary thyroid cancer DICER1 Sarah Leigh marked DICER1 as ready
Inherited non-medullary thyroid cancer DICER1 Sarah Leigh classified DICER1 as green
Inherited non-medullary thyroid cancer DICER1 Sarah Leigh commented on DICER1
Inherited non-medullary thyroid cancer BRAF Sarah Leigh marked BRAF as ready
Inherited non-medullary thyroid cancer WRN Sarah Leigh marked WRN as ready
Inherited non-medullary thyroid cancer SLC5A5 Sarah Leigh marked SLC5A5 as ready
Inherited non-medullary thyroid cancer SLC5A5 Sarah Leigh commented on SLC5A5
Inherited non-medullary thyroid cancer TG Sarah Leigh marked TG as ready
Inherited non-medullary thyroid cancer TG Sarah Leigh commented on TG
Inherited non-medullary thyroid cancer TG Sarah Leigh classified TG as red
Inherited non-medullary thyroid cancer PTEN Sarah Leigh marked PTEN as ready
Inherited non-medullary thyroid cancer PTEN Sarah Leigh commented on PTEN
Inherited non-medullary thyroid cancer PRKAR1A Sarah Leigh marked PRKAR1A as ready
Inherited non-medullary thyroid cancer PRKAR1A Sarah Leigh commented on PRKAR1A
Inherited non-medullary thyroid cancer SRRM2 Sarah Leigh marked SRRM2 as ready
Inherited non-medullary thyroid cancer SRRM2 Sarah Leigh commented on SRRM2
Inherited non-medullary thyroid cancer SRRM2 Sarah Leigh classified SRRM2 as red
Inherited non-medullary thyroid cancer SDHB Sarah Leigh marked SDHB as ready
Inherited non-medullary thyroid cancer SDHB Sarah Leigh classified SDHB as red
Inherited non-medullary thyroid cancer SDHB Sarah Leigh edited their review of SDHB
Inherited non-medullary thyroid cancer SDHB Sarah Leigh commented on SDHB
Inherited non-medullary thyroid cancer GNAS Sarah Leigh commented on GNAS
Inherited non-medullary thyroid cancer GNAS Sarah Leigh added GNAS to panel
Inherited non-medullary thyroid cancer GNAS Sarah Leigh reviewed GNAS
Inherited non-medullary thyroid cancer BRCA2 Sarah Leigh added BRCA2 to panel
Inherited non-medullary thyroid cancer BRCA2 Sarah Leigh reviewed BRCA2
Inherited non-medullary thyroid cancer BRCA1 Sarah Leigh added BRCA1 to panel
Inherited non-medullary thyroid cancer BRCA1 Sarah Leigh reviewed BRCA1
Inherited non-medullary thyroid cancer MSH6 Sarah Leigh classified MSH6 as red
Inherited non-medullary thyroid cancer DICER1 Ellen McDonagh reviewed DICER1
Inherited non-medullary thyroid cancer MEN1 Sarah Leigh added MEN1 to panel
Inherited non-medullary thyroid cancer MEN1 Sarah Leigh reviewed MEN1
Inherited non-medullary thyroid cancer MSH2 Sarah Leigh added MSH2 to panel
Inherited non-medullary thyroid cancer MSH2 Sarah Leigh reviewed MSH2
Inherited non-medullary thyroid cancer MSH6 Sarah Leigh added MSH6 to panel
Inherited non-medullary thyroid cancer MSH6 Sarah Leigh reviewed MSH6
Inherited non-medullary thyroid cancer BRAF Sarah Leigh added BRAF to panel
Inherited non-medullary thyroid cancer BRAF Sarah Leigh reviewed BRAF
Inherited non-medullary thyroid cancer APC Sarah Leigh marked APC as ready
Inherited non-medullary thyroid cancer APC Sarah Leigh commented on APC
Inherited non-medullary thyroid cancer SDHB Emma Woodward added SDHB to panel
Inherited non-medullary thyroid cancer SDHB Emma Woodward reviewed SDHB
Inherited non-medullary thyroid cancer SRRM2 Emma Woodward added SRRM2 to panel
Inherited non-medullary thyroid cancer SRRM2 Emma Woodward reviewed SRRM2
Inherited non-medullary thyroid cancer VTRNA2-1 Emma Woodward reviewed VTRNA2-1
Inherited non-medullary thyroid cancer SRGAP1 Emma Woodward reviewed SRGAP1
Inherited non-medullary thyroid cancer SEC23B Emma Woodward reviewed SEC23B
Inherited non-medullary thyroid cancer PTCSC3 Emma Woodward reviewed PTCSC3
Inherited non-medullary thyroid cancer PTCSC1 Emma Woodward reviewed PTCSC1
Inherited non-medullary thyroid cancer PIK3CA Emma Woodward reviewed PIK3CA
Inherited non-medullary thyroid cancer NKX2-1 Emma Woodward reviewed NKX2-1
Inherited non-medullary thyroid cancer NDUFA13 Emma Woodward commented on NDUFA13
Inherited non-medullary thyroid cancer MINPP1 Emma Woodward edited their review of MINPP1
Inherited non-medullary thyroid cancer MINPP1 Emma Woodward commented on MINPP1
Inherited non-medullary thyroid cancer KISS1R Emma Woodward commented on KISS1R
Inherited non-medullary thyroid cancer HABP2 Emma Woodward reviewed HABP2
Inherited non-medullary thyroid cancer FOXE1 Emma Woodward commented on FOXE1
Inherited non-medullary thyroid cancer FOXE1 Emma Woodward reviewed FOXE1
Inherited non-medullary thyroid cancer DIRAS3 Emma Woodward reviewed DIRAS3
Inherited non-medullary thyroid cancer DICER1 Emma Woodward reviewed DICER1
Inherited non-medullary thyroid cancer SLC5A5 Emma Woodward reviewed SLC5A5
Inherited non-medullary thyroid cancer SLC5A5 Emma Woodward reviewed SLC5A5
Inherited non-medullary thyroid cancer WRN Emma Woodward reviewed WRN
Inherited non-medullary thyroid cancer TG Emma Woodward reviewed TG
Inherited non-medullary thyroid cancer PTEN Emma Woodward reviewed PTEN
Inherited non-medullary thyroid cancer PRKAR1A Emma Woodward reviewed PRKAR1A
Inherited non-medullary thyroid cancer APC Emma Woodward reviewed APC
Inherited non-medullary thyroid cancer PIK3CA Fiona Lalloo reviewed PIK3CA
Inherited non-medullary thyroid cancer PIK3CA Fiona Lalloo commented on PIK3CA
Inherited non-medullary thyroid cancer NKX2-1 Fiona Lalloo reviewed NKX2-1
Inherited non-medullary thyroid cancer NDUFA13 Fiona Lalloo reviewed NDUFA13
Inherited non-medullary thyroid cancer MINPP1 Fiona Lalloo reviewed MINPP1
Inherited non-medullary thyroid cancer KISS1R Fiona Lalloo commented on KISS1R
Inherited non-medullary thyroid cancer KISS1R Fiona Lalloo reviewed KISS1R
Inherited non-medullary thyroid cancer HABP2 Fiona Lalloo reviewed HABP2
Inherited non-medullary thyroid cancer FOXE1 Fiona Lalloo reviewed FOXE1
Inherited non-medullary thyroid cancer DIRAS3 Fiona Lalloo reviewed DIRAS3
Inherited non-medullary thyroid cancer DICER1 Fiona Lalloo reviewed DICER1
Inherited non-medullary thyroid cancer SLC5A5 Fiona Lalloo reviewed SLC5A5
Inherited non-medullary thyroid cancer WRN Fiona Lalloo reviewed WRN
Inherited non-medullary thyroid cancer TG Fiona Lalloo reviewed TG
Inherited non-medullary thyroid cancer PTEN Fiona Lalloo reviewed PTEN
Inherited non-medullary thyroid cancer PRKAR1A Fiona Lalloo reviewed PRKAR1A
Inherited non-medullary thyroid cancer APC Fiona Lalloo reviewed APC
Inherited non-medullary thyroid cancer WRN Sarah Leigh edited their review of WRN
Inherited non-medullary thyroid cancer WRN Sarah Leigh added WRN to panel
Inherited non-medullary thyroid cancer WRN Sarah Leigh reviewed WRN