Familial breast cancer
Gene: BRIP1Comment on list classification: Intermediate penetrance variant; expert reviewers have marked as unsuitable for diagnostic use at the current time.Created: 29 Jan 2016, 1:56 p.m.
Intermediate penetrance (max RR~3). Equivocal regarding susceptibility to BC, better data for OC.Created: 2 Oct 2015, 10:37 a.m.
There are no good data linking loss-of-function variants in this gene to breast cancer susceptibilityCreated: 28 Sep 2015, 5:34 p.m.
Phenotypes for gene: BRIP1 were changed from ?Breast cancer, early-onset, 114480; Fanconi anemia, complementation group J, 609054; Breast and Ovarian Cancer; Breast Cancer to {Breast cancer, early-onset, susceptibility to}, OMIM:114480
This gene has been classified as Red List (Low Evidence).
This gene has been classified as Red List (Low Evidence).
Model of inheritance for gene BRIP1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
BRIP1 was added to Familial breast cancerpanel. Sources: Illumina TruGenome Clinical Sequencing Services
BRIP1 was added to Familial breast cancerpanel. Sources: Emory Genetics Laboratory
BRIP1 was added to Familial breast cancerpanel. Sources: Radboud University Medical Center, Nijmegen