Familial breast cancer
Gene: CDH1
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Lobular breast cancer
Publications
Little evidence for susceptibility to ductal BC. Potential for harm wrt prophylactic gastrectomyCreated: 7 Jul 2017, 1:02 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
lobular BC
Comment on list classification: Inclusion of this gene on this panel was raised within the Inherited Cancer Predisposition GeCIP Domain group July 5th, and the conclusion was that this gene should not be included on this panel for reporting. Demoted to red.Created: 18 Jul 2017, 12:49 p.m.
Comment on list classification: After internal discussion, it was decided this gene should be green.Created: 29 Feb 2016, 4:59 p.m.
Comment when marking as ready: Not yet sufficient evidence for diagnostic use. Keep under review.Created: 29 Jan 2016, 2:25 p.m.
Comment on list classification: Possible association with predisposition to lobular breast cancer. At present insufficient evidence for diagnostic use.Created: 29 Jan 2016, 2:22 p.m.
Phenotypes for CDH1 were set to Endometrial carcinoma, somatic, 608089; Ovarian carcinoma, somatic, 167000; {Breast cancer, lobular}, 114480; Gastric cancer, familial diffuse, with or without cleft lip and/or palate, 137215; {Prostate cancer, susceptibility to}, 176807; High Risk Breast Cancer; Breast and Ovarian Cancer; lobular breast cancer
This gene has been classified as Red List (Low Evidence).
This gene has been classified as Green List (High Evidence).
This gene has been classified as Red List (Low Evidence).
Mode of inheritance for CDH1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
This gene has been classified as Red List (Low Evidence).
CDH1 was added to Familial breast cancerpanel. Sources: Emory Genetics Laboratory
CDH1 was added to Familial breast cancerpanel. Sources: Radboud University Medical Center, Nijmegen