Familial breast cancer
Gene: RAD51C
associated with increased OvCa risk, association with breast cancer less clear.Created: 29 Aug 2017, 12:55 p.m.
OR~6 for OC. Currently in clinical use in NHSCreated: 2 Oct 2015, 10:58 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
ovarian cancer
LoF variants clearly associated with ovarian cancer susceptibility, but penetrance estimates too imprecise to warrant clinical implementations. No clear association with breast cancer risk.Created: 28 Sep 2015, 5:42 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Ovarian cancer
This gene has been classified as Green List (High Evidence).
Mode of inheritance for RAD51C was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Model of inheritance for gene RAD51C was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
RAD51C was added to Familial breast cancerpanel. Sources: Illumina TruGenome Clinical Sequencing Services
RAD51C was added to Familial breast cancerpanel. Sources: Emory Genetics Laboratory
RAD51C was added to Familial breast cancerpanel. Sources: Radboud University Medical Center, Nijmegen