Familial breast cancer

Gene: RAD51C

Green List (high evidence)

RAD51C (RAD51 paralog C)
EnsemblGeneIds (GRCh38): ENSG00000108384
EnsemblGeneIds (GRCh37): ENSG00000108384
OMIM: 602774, Gene2Phenotype
RAD51C is in 22 panels

3 reviews

Treena Cranston (Oxford)

Red List (low evidence)

associated with increased OvCa risk, association with breast cancer less clear.
Created: 29 Aug 2017, 12:55 p.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

OR~6 for OC. Currently in clinical use in NHS
Created: 2 Oct 2015, 10:58 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
ovarian cancer

Paul Pharoah (University of Cambridge)

Red List (low evidence)

LoF variants clearly associated with ovarian cancer susceptibility, but penetrance estimates too imprecise to warrant clinical implementations. No clear association with breast cancer risk.
Created: 28 Sep 2015, 5:42 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Ovarian cancer

History Filter Activity

29 Jan 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

29 Jan 2016, Gel status: 3

Set Mode of Inheritance

Ellen Thomas (Genomics England Curator)

Mode of inheritance for RAD51C was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

27 Jul 2015, Gel status: 3

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene RAD51C was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

27 Jul 2015, Gel status: 3

Added New Source

Eik Haraldsdottir (Genomics England)

RAD51C was added to Familial breast cancerpanel. Sources: Illumina TruGenome Clinical Sequencing Services

27 Jul 2015, Gel status: 2

Added New Source

Eik Haraldsdottir (Genomics England)

RAD51C was added to Familial breast cancerpanel. Sources: Emory Genetics Laboratory

27 Jul 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

RAD51C was added to Familial breast cancerpanel. Sources: Radboud University Medical Center, Nijmegen