Familial breast cancer

Gene: RAD51D

Green List (high evidence)

RAD51D (RAD51 paralog D)
EnsemblGeneIds (GRCh38): ENSG00000185379
EnsemblGeneIds (GRCh37): ENSG00000185379
OMIM: 602954, Gene2Phenotype
RAD51D is in 6 panels

4 reviews

Paul Pharoah (University of Cambridge)

Red List (low evidence)

Treena Cranston (Oxford)

Red List (low evidence)

associated with increased risk of Ovarian cancer (~6 fold risk), breast cancer risks less clear, Loveday et al, 2011 suggest ~1.3fold risk
Created: 29 Aug 2017, 12:53 p.m.

Ellen Thomas (Genomics England Curator)

Comment when marking as ready: Association with ovarian cancer, in clinical use.
Created: 29 Jan 2016, 2:07 p.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

OR~6 for OC. Currently in clinical use in NHS
Created: 2 Oct 2015, 10:58 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Illumina TruGenome Clinical Sequencing Services
  • Emory Genetics Laboratory
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • {Breast-ovarian cancer, familial, susceptibility to, 4}, 614291
  • Breast and Ovarian Cancer
  • Breast and Ovarian Cancer Susceptibility
OMIM
602954
Clinvar variants
Variants in RAD51D
Penetrance
Complete
Panels with this gene

History Filter Activity

29 Jan 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen Thomas (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

29 Jan 2016, Gel status: 3

Set Mode of Inheritance

Ellen Thomas (Genomics England Curator)

Mode of inheritance for RAD51D was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

27 Jul 2015, Gel status: 3

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene RAD51D was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

27 Jul 2015, Gel status: 3

Added New Source

Eik Haraldsdottir (Genomics England)

RAD51D was added to Familial breast cancerpanel. Sources: Illumina TruGenome Clinical Sequencing Services

27 Jul 2015, Gel status: 2

Added New Source

Eik Haraldsdottir (Genomics England)

RAD51D was added to Familial breast cancerpanel. Sources: Emory Genetics Laboratory

27 Jul 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

RAD51D was added to Familial breast cancerpanel. Sources: Radboud University Medical Center, Nijmegen