Familial breast cancer
Gene: RAD51CEnsemblGeneIds (GRCh38): ENSG00000108384
EnsemblGeneIds (GRCh37): ENSG00000108384
OMIM: 602774, Gene2Phenotype
RAD51C is in 21 panels
3 reviews
Treena Cranston (Oxford)
associated with increased OvCa risk, association with breast cancer less clear.Created: 29 Aug 2017, 12:55 p.m.
Clare Turnbull (Queen Mary University London)
OR~6 for OC. Currently in clinical use in NHSCreated: 2 Oct 2015, 10:58 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
ovarian cancer
Paul Pharoah (University of Cambridge)
LoF variants clearly associated with ovarian cancer susceptibility, but penetrance estimates too imprecise to warrant clinical implementations. No clear association with breast cancer risk.Created: 28 Sep 2015, 5:42 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Ovarian cancer
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Illumina TruGenome Clinical Sequencing Services
- Emory Genetics Laboratory
- Radboud University Medical Center, Nijmegen
- Phenotypes
-
- Fanconi anemia, complementation group O, 613390
- {Breast-ovarian cancer, familial, susceptibility to, 3}, 613399
- Breast and Ovarian Cancer
- Breast and Ovarian Cancer Susceptibility
- OMIM
- 602774
- Clinvar variants
- Variants in RAD51C
- Penetrance
- Complete
- Panels with this gene
-
- Inherited ovarian cancer (without breast cancer)
- Fetal anomalies
- Severe microcephaly
- Childhood solid tumours cancer susceptibility
- Radial dysplasia
- Intellectual disability
- Familial breast cancer
- Ovarian cancer pertinent cancer susceptibility
- Inherited breast cancer and ovarian cancer
- Cytopenias and congenital anaemias
- Limb disorders
- DDG2P
- Haematological malignancies cancer susceptibility
- Pigmentary skin disorders
- COVID-19 research
- Neurofibromatosis Type 1
- Haematological malignancies for rare disease
- Adult solid tumours for rare disease
- Confirmed Fanconi anaemia or Bloom syndrome
- Childhood solid tumours
- Adult solid tumours cancer susceptibility
History Filter Activity
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Set Mode of Inheritance
Ellen Thomas (Genomics England Curator)Mode of inheritance for RAD51C was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Set Mode of Inheritance
Eik Haraldsdottir (Genomics England)Model of inheritance for gene RAD51C was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Added New Source
Eik Haraldsdottir (Genomics England)RAD51C was added to Familial breast cancerpanel. Sources: Illumina TruGenome Clinical Sequencing Services
Added New Source
Eik Haraldsdottir (Genomics England)RAD51C was added to Familial breast cancerpanel. Sources: Emory Genetics Laboratory
Added New Source
Eik Haraldsdottir (Genomics England)RAD51C was added to Familial breast cancerpanel. Sources: Radboud University Medical Center, Nijmegen