Familial breast cancer
Gene: STK11
STK11 (serine/threonine kinase 11)
EnsemblGeneIds (GRCh38): ENSG00000118046
EnsemblGeneIds (GRCh37): ENSG00000118046
OMIM: 602216, Gene2Phenotype
STK11 is in 14 panels
EnsemblGeneIds (GRCh38): ENSG00000118046
EnsemblGeneIds (GRCh37): ENSG00000118046
OMIM: 602216, Gene2Phenotype
STK11 is in 14 panels
2 reviews
Paul Pharoah (University of Cambridge)
Ellen Thomas (Genomics England Curator)
Comment on list classification: Up to 50% risk of breast cancer in Peutz-Jeghers syndrome.Created: 29 Jan 2016, 4:56 p.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Emory Genetics Laboratory
- Phenotypes
-
- High Risk Breast Cancer
- Breast and Ovarian Cancer
- OMIM
- 602216
- Clinvar variants
- Variants in STK11
- Penetrance
- Complete
- Publications
-
- PMID: 11113065
- Panels with this gene
-
- Childhood solid tumours cancer susceptibility
- Colorectal cancer pertinent cancer susceptibility
- Adult solid tumours for rare disease
- Familial breast cancer
- Palmoplantar keratodermas
- GI tract tumours
- Multiple monogenic benign skin tumours
- Childhood solid tumours
- Adult solid tumours cancer susceptibility
- Peutz Jeghers Syndrome
- Inherited pancreatic cancer
- Inherited ovarian cancer (without breast cancer)
- Inherited polyposis and early onset colorectal cancer - germline testing
- Pigmentary skin disorders
History Filter Activity
29 Jan 2016, Gel status: 4
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
29 Jan 2016, Gel status: 4
Set publications
Ellen Thomas (Genomics England Curator)Publications for STK11 were set to PMID: 11113065
29 Jan 2016, Gel status: 4
Set Mode of Inheritance
Ellen Thomas (Genomics England Curator)Mode of inheritance for STK11 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
29 Jan 2016, Gel status: 4
Gene classified by Genomics England curator
Ellen Thomas (Genomics England Curator)This gene has been classified as Green List (High Evidence).
27 Jul 2015, Gel status: 1
Added New Source
Eik Haraldsdottir (Genomics England)STK11 was added to Familial breast cancerpanel. Sources: Emory Genetics Laboratory