Cytopenias and congenital anaemias
Gene: FBXW7
FBXW7 (F-box and WD repeat domain containing 7)
EnsemblGeneIds (GRCh38): ENSG00000109670
EnsemblGeneIds (GRCh37): ENSG00000109670
OMIM: 606278, Gene2Phenotype
FBXW7 is in 4 panels
EnsemblGeneIds (GRCh38): ENSG00000109670
EnsemblGeneIds (GRCh37): ENSG00000109670
OMIM: 606278, Gene2Phenotype
FBXW7 is in 4 panels
2 reviews
Ellen McDonagh (Genomics England Curator)
Comment on list classification: The COSMIC census gene list indicates that variants are somatic for colorectal, endometrial and T-cell acute lymphoblastic leukaemia. Information on OMIM indicates that somatic variants have been identified in cancer cell lines. Not associated with a disorder in OMIM or Gene2Phenotype. Literature search confirmed this is a somatic gene.Created: 7 Mar 2017, 3:18 p.m.
BRIDGE consortium (NIHRBR-RD)
Mode of inheritance
Unknown
Phenotypes
Acute lymphoblastic leukemia (ALL)
Variants in this GENE are reported as part of current diagnostic practice
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Expert Review Red
- BRIDGE consortium (NIHRBR-RD)
- Phenotypes
-
- Acute lymphoblastic leukemia (ALL)
- Tags
- OMIM
- 606278
- Clinvar variants
- Variants in FBXW7
- Penetrance
- Complete
- Mode of Pathogenicity
- Other - please provide details in the comments
- Panels with this gene
History Filter Activity
11 Mar 2017, Gel status: 1
panel promoted to version 1
Arianna Tucci (Genomics England Curator)Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.
7 Mar 2017, Gel status: 1
Set mode of pathogenicity
Ellen McDonagh (Genomics England Curator)Mode of pathogenicity for FBXW7 was changed to Other - please provide details in the comments
7 Mar 2017, Gel status: 1
Gene classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)This gene has been classified as Red List (Low Evidence).
7 Mar 2017, Gel status: 1
Gene classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)This gene has been classified as Red List (Low Evidence).
17 Feb 2017, Gel status: 0
Created
Louise Daugherty (Genomics England Curator)FBXW7 was created by LouiseD
17 Feb 2017, Gel status: 0
Added New Source
Louise Daugherty (Genomics England Curator)FBXW7 was added to Cytopaenias and congenital anaemiaspanel. Sources: BRIDGE consortium (NIHRBR-RD)