GI tract tumours

Gene: ENG

Red List (low evidence)

ENG (endoglin)
EnsemblGeneIds (GRCh38): ENSG00000106991
EnsemblGeneIds (GRCh37): ENSG00000106991
OMIM: 131195, Gene2Phenotype
ENG is in 10 panels

2 reviews

Ian Frayling (Cardiff University)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Ellen Thomas (Genomics England Curator)

Comment when marking as ready: Insufficient evidence for ENG causing juvenile polyposis at this time.
Created: 29 Jan 2016, 3:23 p.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Illumina TruGenome Clinical Sequencing Services
  • Expert Review Red
Phenotypes
  • Juvenile Polyposis
OMIM
131195
Clinvar variants
Variants in ENG
Penetrance
Complete
Panels with this gene

History Filter Activity

12 May 2017, Gel status: 1

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

This panel has been formed as a result of merging Familial colon cancer (Version 1.5), Multiple bowel polyps (Version 1.9), Peutz-Jeghers syndrome (Version 0.20) panels and copying the reviews from each panel into this united GI Tract panel

11 May 2017, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

ENG was added to GI tractpanel. Sources: Illumina TruGenome Clinical Sequencing Services,Expert Review Red

11 May 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

ENG was created by ellenmcdonagh