GI tract tumoursGene: CDH1
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.
Created: 31 Jul 2019, 12:28 p.m. | Last Modified: 31 Jul 2019, 12:28 p.m.
Panel Version: 1.13
Comment on list classification: Discussed with CT - penetrance not high enough for clinical utility at this time.
Created: 10 May 2016, 8:20 p.m.
Good evidence that CDH1 predisposes modestly to rectum (and possibly) colon cancer
Created: 8 Dec 2015, 2:14 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
This panel has been formed as a result of merging Familial colon cancer (Version 1.5), Multiple bowel polyps (Version 1.9), Peutz-Jeghers syndrome (Version 0.20) panels and copying the reviews from each panel into this united GI Tract panel
This gene has been classified as Amber List (Moderate Evidence).
CDH1 was created by ellenmcdonagh
CDH1 was added to GI tractpanel. Sources: Emory Genetics Laboratory,Expert Review Red